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Functional connectivity of the right inferior frontal gyrus and orbitofrontal cortex in depression
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Feng, Jianfeng, Xie, Peng, Zhou, Qunjie, Dai, Dan, Qiu, Jiang, Wei, Dongtao, Du, Jingnan, Cheng, Wei and Rolls, Edmund T. (2020) Functional connectivity of the right inferior frontal gyrus and orbitofrontal cortex in depression. Social Cognitive and Affective Neuroscience, 15 (1). pp. 75-86. doi:10.1093/scan/nsaa014
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Official URL: http://dx.doi.org/10.1093/scan/nsaa014
Abstract
The orbitofrontal cortex extends into the laterally adjacent inferior frontal gyrus. We analyzed how voxel-level functional connectivity of the inferior frontal gyrus and orbitofrontal cortex is related to depression in 282 people with major depressive disorder (125 were unmedicated) and 254 controls, using FDR correction P < 0.05 for pairs of voxels. In the unmedicated group, higher functional connectivity was found of the right inferior frontal gyrus with voxels in the lateral and medial orbitofrontal cortex, cingulate cortex, temporal lobe, angular gyrus, precuneus, hippocampus and frontal gyri. In medicated patients, these functional connectivities were lower and toward those in controls. Functional connectivities between the lateral orbitofrontal cortex and the precuneus, posterior cingulate cortex, inferior frontal gyrus, ventromedial prefrontal cortex and the angular and middle frontal gyri were higher in unmedicated patients, and closer to controls in medicated patients. Medial orbitofrontal cortex voxels had lower functional connectivity with temporal cortex areas, the parahippocampal gyrus and fusiform gyrus, and medication did not result in these being closer to controls. These findings are consistent with the hypothesis that the orbitofrontal cortex is involved in depression, and can influence mood and behavior via the right inferior frontal gyrus, which projects to premotor cortical areas.
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science > Computer Science | ||||||
| Library of Congress Subject Headings (LCSH): | Brain -- Localization of functions, Brain mapping, Computational neuroscience, Prefrontal cortex, Frontal lobes | ||||||
| Journal or Publication Title: | Social Cognitive and Affective Neuroscience | ||||||
| Publisher: | Oxford University Press | ||||||
| ISSN: | 1749-5024 | ||||||
| Official Date: | 28 January 2020 | ||||||
| Dates: |
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| Volume: | 15 | ||||||
| Number: | 1 | ||||||
| Page Range: | pp. 75-86 | ||||||
| DOI: | 10.1093/scan/nsaa014 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access |
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