The Library
Elastomeric polyamide biomaterials with stereochemically tuneable mechanical properties and shape memory
Tools
Worch, Joshua C., Weems, Andrew C., Yu, Jiayi, Arno, Maria C., Wilks, Thomas R., Huckstepp, Robert T. R., O’Reilly, Rachel K., Becker, Matthew L. and Dove, Andrew P. (2020) Elastomeric polyamide biomaterials with stereochemically tuneable mechanical properties and shape memory. Nature Communications, 11 (1). p. 3250. doi:10.1038/s41467-020-16945-8 ISSN 2041-1723.
|
PDF
WRAP-Elastomeric-polyamide-biomaterials-shape-memory-Huckstepp-2020.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (2208Kb) | Preview |
Official URL: https://doi.org/10.1038/s41467-020-16945-8
Abstract
Abstract: Biocompatible polymers are widely used in tissue engineering and biomedical device applications. However, few biomaterials are suitable for use as long-term implants and these examples usually possess limited property scope, can be difficult to process, and are non-responsive to external stimuli. Here, we report a class of easily processable polyamides with stereocontrolled mechanical properties and high-fidelity shape memory behaviour. We synthesise these materials using the efficient nucleophilic thiol-yne reaction between a dipropiolamide and dithiol to yield an α,β − unsaturated carbonyl moiety along the polymer backbone. By rationally exploiting reaction conditions, the alkene stereochemistry is modulated between 35–82% cis content and the stereochemistry dictates the bulk material properties such as tensile strength, modulus, and glass transition. Further access to materials possessing a broader range of thermal and mechanical properties is accomplished by polymerising a variety of commercially available dithiols with the dipropiolamide monomer.
Item Type: | Journal Article | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Subjects: | Q Science > QD Chemistry R Medicine > R Medicine (General) T Technology > TA Engineering (General). Civil engineering (General) |
|||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||||||||
SWORD Depositor: | Library Publications Router | |||||||||||||||
Library of Congress Subject Headings (LCSH): | Polymeric composites, Polymeric composites -- Mechanical properties, Tissue engineering, Biomedical materials, Polyamides | |||||||||||||||
Journal or Publication Title: | Nature Communications | |||||||||||||||
Publisher: | Nature Publishing Group UK | |||||||||||||||
ISSN: | 2041-1723 | |||||||||||||||
Official Date: | 26 June 2020 | |||||||||||||||
Dates: |
|
|||||||||||||||
Volume: | 11 | |||||||||||||||
Number: | 1 | |||||||||||||||
Page Range: | p. 3250 | |||||||||||||||
DOI: | 10.1038/s41467-020-16945-8 | |||||||||||||||
Status: | Peer Reviewed | |||||||||||||||
Publication Status: | Published | |||||||||||||||
Reuse Statement (publisher, data, author rights): | ** From Springer Nature via Jisc Publications Router ** History: received 29-06-2019; accepted 27-05-2020; registration 04-06-2020; online 26-06-2020; epub 26-06-2020; collection 12-2020. ** Licence for this article: https://creativecommons.org/licenses/by/4.0/ | |||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
Date of first compliant deposit: | 30 June 2020 | |||||||||||||||
Date of first compliant Open Access: | 1 July 2020 | |||||||||||||||
RIOXX Funder/Project Grant: |
|
|||||||||||||||
Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year