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Purines : from diagnostic biomarkers to therapeutic agents in brain injury
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Frenguelli, Bruno G. and Dale, Nicholas (2020) Purines : from diagnostic biomarkers to therapeutic agents in brain injury. Neuroscience bulletin, 36 . pp. 1315-1326. doi:10.1007/s12264-020-00529-z
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WRAP-Purines-diagnostic-biomarkers-therapeutic-agents-brain-injury-Frenguelli-2020.pdf - Accepted Version - Requires a PDF viewer. Download (3148Kb) | Preview |
Official URL: https://doi.org/10.1007/s12264-020-00529-z
Abstract
The purines constitute a family of inter-related compounds that serve a broad range of important intracellular and extracellular biological functions. In particular, adenosine triphosphate (ATP) and its metabolite and precursor, adenosine, regulate a wide variety of cellular and systems-level physiological processes extending from ATP acting as the cellular energy currency, to the adenosine arising from the depletion of cellular ATP and responding to reduce energy demand and hence to preserve ATP during times of metabolic stress. This inter-relationship provides opportunities for both the diagnosis of energy depletion during conditions such as stroke, and the replenishment of ATP after such events. In this review we address these opportunities and the broad potential of purines as diagnostics and restorative agents.
| Item Type: | Journal Article | |||||||||||||||||||||
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| Subjects: | Q Science > QH Natural history Q Science > QP Physiology R Medicine > RC Internal medicine R Medicine > RD Surgery |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) | |||||||||||||||||||||
| SWORD Depositor: | Library Publications Router | |||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Purines , Adenosine triphosphate, Adenine , Biochemical markers , Cerebral ischemia, Cerebrovascular disease , Brain -- Wounds and injuries | |||||||||||||||||||||
| Journal or Publication Title: | Neuroscience bulletin | |||||||||||||||||||||
| Publisher: | Springer | |||||||||||||||||||||
| ISSN: | 1995-8218 | |||||||||||||||||||||
| Official Date: | November 2020 | |||||||||||||||||||||
| Dates: |
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| Volume: | 36 | |||||||||||||||||||||
| Page Range: | pp. 1315-1326 | |||||||||||||||||||||
| DOI: | 10.1007/s12264-020-00529-z | |||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||
| Publisher Statement: | This is a post-peer-review, pre-copyedit version of an article published in Neuroscience bulletin. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12264-020-00529-z | |||||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||||||||
| Description: | Free access |
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| RIOXX Funder/Project Grant: |
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