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Purines : from diagnostic biomarkers to therapeutic agents in brain injury

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Frenguelli, Bruno G. and Dale, Nicholas (2020) Purines : from diagnostic biomarkers to therapeutic agents in brain injury. Neuroscience bulletin, 36 . pp. 1315-1326. doi:10.1007/s12264-020-00529-z

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Official URL: https://doi.org/10.1007/s12264-020-00529-z

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Abstract

The purines constitute a family of inter-related compounds that serve a broad range of important intracellular and extracellular biological functions. In particular, adenosine triphosphate (ATP) and its metabolite and precursor, adenosine, regulate a wide variety of cellular and systems-level physiological processes extending from ATP acting as the cellular energy currency, to the adenosine arising from the depletion of cellular ATP and responding to reduce energy demand and hence to preserve ATP during times of metabolic stress. This inter-relationship provides opportunities for both the diagnosis of energy depletion during conditions such as stroke, and the replenishment of ATP after such events. In this review we address these opportunities and the broad potential of purines as diagnostics and restorative agents.

Item Type: Journal Article
Subjects: Q Science > QH Natural history
Q Science > QP Physiology
R Medicine > RC Internal medicine
R Medicine > RD Surgery
Divisions: Faculty of Science > Life Sciences (2010- )
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Purines , Adenosine triphosphate, Adenine , Biochemical markers , Cerebral ischemia, Cerebrovascular disease , Brain -- Wounds and injuries
Journal or Publication Title: Neuroscience bulletin
Publisher: Springer
ISSN: 1995-8218
Official Date: November 2020
Dates:
DateEvent
November 2020Published
15 June 2020Available
30 March 2020Accepted
Volume: 36
Page Range: pp. 1315-1326
DOI: 10.1007/s12264-020-00529-z
Status: Peer Reviewed
Publication Status: Published
Publisher Statement: This is a post-peer-review, pre-copyedit version of an article published in Neuroscience bulletin. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12264-020-00529-z
Access rights to Published version: Restricted or Subscription Access
Description:

Free access

RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDBritish Society for Research on Ageinghttp://dx.doi.org/10.13039/100011701
UNSPECIFIEDRoyal Societyhttp://dx.doi.org/10.13039/501100000288
UNSPECIFIEDWellcome Trusthttp://dx.doi.org/10.13039/100010269
UNSPECIFIED[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
UNSPECIFIEDRosetrees Trusthttp://dx.doi.org/10.13039/501100000833
UNSPECIFIEDUniversity of Warwickhttp://dx.doi.org/10.13039/501100000741

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