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Evaluation of transdermal drug delivery using terahertz pulsed imaging

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Wang, Jiarui, Lindley-Hatcher, Hannah, liu, Kai and Pickwell-MacPherson, Emma (2020) Evaluation of transdermal drug delivery using terahertz pulsed imaging. Biomedical Optics Express, 11 (8). pp. 4484-4490. doi:10.1364/BOE.394436 ISSN 2156-7085.

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Official URL: http://dx.doi.org/10.1364/BOE.394436

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Abstract

Transdermal drug delivery (TDD) is widely used for painless dosing due to its minimally invasive nature compared to hypodermic needle injection and its avoidance of the gastrointestinal tract. However, the stratum corneum obstructs the permeation of drugs into skin. Microneedle and nanoneedle patches are ways to enhance this permeation. In this work, terahertz (THz) imaging is utilized to compare the efficacy of different TDD methods including topical application and via a needle patch. Our work shows the feasibility and potential of using THz imaging to quantify and evaluate different transdermal application methods.

Item Type: Journal Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
T Technology > TK Electrical engineering. Electronics Nuclear engineering
Divisions: Faculty of Science, Engineering and Medicine > Science > Physics
Library of Congress Subject Headings (LCSH): Transdermal medication, Terahertz technology , Submillimeter waves
Journal or Publication Title: Biomedical Optics Express
Publisher: Optical Society of America
ISSN: 2156-7085
Official Date: 2020
Dates:
DateEvent
2020Published
16 June 2020Accepted
Volume: 11
Number: 8
Page Range: pp. 4484-4490
DOI: 10.1364/BOE.394436
Status: Peer Reviewed
Publication Status: Published
Reuse Statement (publisher, data, author rights): © 2020 Optical Society of America. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 30 June 2020
Date of first compliant Open Access: 30 June 2020
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
Wolfson Merit AwardRoyal Societyhttp://dx.doi.org/10.13039/501100000288
EP/S021442/1[EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
14206717Research Grants Council, University Grants Committeehttp://dx.doi.org/10.13039/501100002920

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