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Evaluation of transdermal drug delivery using terahertz pulsed imaging
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Wang, Jiarui, Lindley-Hatcher, Hannah, liu, Kai and Pickwell-MacPherson, Emma (2020) Evaluation of transdermal drug delivery using terahertz pulsed imaging. Biomedical Optics Express, 11 (8). pp. 4484-4490. doi:10.1364/BOE.394436
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WRAP-Evaluation-transdermal-drug-delivery-terahertz-pulsed-imaging-Lindley-Hatcher-2020.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1316Kb) | Preview |
Official URL: http://dx.doi.org/10.1364/BOE.394436
Abstract
Transdermal drug delivery (TDD) is widely used for painless dosing due to its minimally invasive nature compared to hypodermic needle injection and its avoidance of the gastrointestinal tract. However, the stratum corneum obstructs the permeation of drugs into skin. Microneedle and nanoneedle patches are ways to enhance this permeation. In this work, terahertz (THz) imaging is utilized to compare the efficacy of different TDD methods including topical application and via a needle patch. Our work shows the feasibility and potential of using THz imaging to quantify and evaluate different transdermal application methods.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | R Medicine > RM Therapeutics. Pharmacology T Technology > TK Electrical engineering. Electronics Nuclear engineering |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||||||||||
| Library of Congress Subject Headings (LCSH): | Transdermal medication, Terahertz technology , Submillimeter waves | ||||||||||||
| Journal or Publication Title: | Biomedical Optics Express | ||||||||||||
| Publisher: | Optical Society of America | ||||||||||||
| ISSN: | 2156-7085 | ||||||||||||
| Official Date: | 2020 | ||||||||||||
| Dates: |
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| Volume: | 11 | ||||||||||||
| Number: | 8 | ||||||||||||
| Page Range: | pp. 4484-4490 | ||||||||||||
| DOI: | 10.1364/BOE.394436 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Reuse Statement (publisher, data, author rights): | © 2020 Optical Society of America. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved. | ||||||||||||
| Access rights to Published version: | Open Access | ||||||||||||
| RIOXX Funder/Project Grant: |
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