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A nuclear role for Atg8-family proteins

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Jacomin, Anne-Claire, Petridi, Stavroula, Di Monaco, Marisa and Nezis, Ioannis P. (2020) A nuclear role for Atg8-family proteins. Autophagy, 16 (9). pp. 1721-1723. doi:10.1080/15548627.2020.1794356 ISSN 1554-8627.

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Official URL: https://doi.org/10.1080/15548627.2020.1794356

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Abstract

Despite the growing evidence that the macroautophagy/autophagy-related protein LC3 is localized in the nucleus, why and how it is targeted to the nucleus are poorly understood. In our recent study, we found that transcription factor seq (sequoia) interacts via its LIR motif with Atg8a, the Drosophila homolog of LC3, to negatively regulate the transcription of autophagy genes. Atg8a was found to also interact with the nuclear acetyltransferase complex subunit YL-1 and deacetylase Sirt2. Modulation of the acetylation status of Atg8a by YL-1 and Sirt2 affects the interaction between seq and Atg8a, and controls the induction of autophagy. Our work revealed a novel nuclear role for Atg8a, which is linked with the transcriptional regulation of autophagy genes.

Item Type: Journal Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Autophagic vacuoles, Cell death, Cytology -- Research, Protein kinases, Drosophila -- Genetics
Journal or Publication Title: Autophagy
Publisher: Landes Bioscience
ISSN: 1554-8627
Official Date: 18 July 2020
Dates:
DateEvent
18 July 2020Published
26 June 2020Accepted
Volume: 16
Number: 9
Page Range: pp. 1721-1723
DOI: 10.1080/15548627.2020.1794356
Status: Peer Reviewed
Publication Status: Published
Reuse Statement (publisher, data, author rights): โ€œThis is an Accepted Manuscript of an article published by Taylor & Francis in Autophagy on 18/07/2020, available online: http://www.tandfonline.com/10.1080/15548627.2020.1794356
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 2 July 2020
Date of first compliant Open Access: 18 July 2021
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
BB/P007856/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
RPG-2017-023Leverhulme Trusthttp://dx.doi.org/10.13039/501100000275
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