The Library
A nuclear role for Atg8-family proteins
Tools
Tools
Tools
Jacomin, Anne-Claire, Petridi, Stavroula, Di Monaco, Marisa and Nezis, Ioannis P. (2020) A nuclear role for Atg8-family proteins. Autophagy, 16 (9). pp. 1721-1723. doi:10.1080/15548627.2020.1794356 ISSN 1554-8627.
|
PDF
WRAP-Nuclear-role-Atg8-family-proteins-Nezis-2020.pdf - Accepted Version - Requires a PDF viewer. Download (1151Kb) | Preview |
Official URL: https://doi.org/10.1080/15548627.2020.1794356
Abstract
Despite the growing evidence that the macroautophagy/autophagy-related protein LC3 is localized in the nucleus, why and how it is targeted to the nucleus are poorly understood. In our recent study, we found that transcription factor seq (sequoia) interacts via its LIR motif with Atg8a, the Drosophila homolog of LC3, to negatively regulate the transcription of autophagy genes. Atg8a was found to also interact with the nuclear acetyltransferase complex subunit YL-1 and deacetylase Sirt2. Modulation of the acetylation status of Atg8a by YL-1 and Sirt2 affects the interaction between seq and Atg8a, and controls the induction of autophagy. Our work revealed a novel nuclear role for Atg8a, which is linked with the transcriptional regulation of autophagy genes.
| Item Type: | Journal Article | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QH Natural history > QH426 Genetics | |||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||
| Library of Congress Subject Headings (LCSH): | Autophagic vacuoles, Cell death, Cytology -- Research, Protein kinases, Drosophila -- Genetics | |||||||||
| Journal or Publication Title: | Autophagy | |||||||||
| Publisher: | Landes Bioscience | |||||||||
| ISSN: | 1554-8627 | |||||||||
| Official Date: | 18 July 2020 | |||||||||
| Dates: |
|
|||||||||
| Volume: | 16 | |||||||||
| Number: | 9 | |||||||||
| Page Range: | pp. 1721-1723 | |||||||||
| DOI: | 10.1080/15548627.2020.1794356 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Reuse Statement (publisher, data, author rights): | โThis is an Accepted Manuscript of an article published by Taylor & Francis in Autophagy on 18/07/2020, available online: http://www.tandfonline.com/10.1080/15548627.2020.1794356 | |||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||
| Date of first compliant deposit: | 2 July 2020 | |||||||||
| Date of first compliant Open Access: | 18 July 2021 | |||||||||
| RIOXX Funder/Project Grant: |
|
|||||||||
| Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
