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A nuclear role for Atg8-family proteins
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Jacomin, Anne-Claire, Petridi, Stavroula, Di Monaco, Marisa and Nezis, Ioannis P. (2020) A nuclear role for Atg8-family proteins. Autophagy, 16 (9). pp. 1721-1723. doi:10.1080/15548627.2020.1794356
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WRAP-Nuclear-role-Atg8-family-proteins-Nezis-2020.pdf - Accepted Version - Requires a PDF viewer. Download (1151Kb) | Preview |
Official URL: https://doi.org/10.1080/15548627.2020.1794356
Abstract
Despite the growing evidence that the macroautophagy/autophagy-related protein LC3 is localized in the nucleus, why and how it is targeted to the nucleus are poorly understood. In our recent study, we found that transcription factor seq (sequoia) interacts via its LIR motif with Atg8a, the Drosophila homolog of LC3, to negatively regulate the transcription of autophagy genes. Atg8a was found to also interact with the nuclear acetyltransferase complex subunit YL-1 and deacetylase Sirt2. Modulation of the acetylation status of Atg8a by YL-1 and Sirt2 affects the interaction between seq and Atg8a, and controls the induction of autophagy. Our work revealed a novel nuclear role for Atg8a, which is linked with the transcriptional regulation of autophagy genes.
| Item Type: | Journal Article | |||||||||
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| Subjects: | Q Science > QH Natural history > QH426 Genetics | |||||||||
| Divisions: | Faculty of Science > Life Sciences (2010- ) | |||||||||
| Library of Congress Subject Headings (LCSH): | Autophagic vacuoles, Cell death, Cytology -- Research, Protein kinases, Drosophila -- Genetics | |||||||||
| Journal or Publication Title: | Autophagy | |||||||||
| Publisher: | Landes Bioscience | |||||||||
| ISSN: | 1554-8627 | |||||||||
| Official Date: | 18 July 2020 | |||||||||
| Dates: |
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| Volume: | 16 | |||||||||
| Number: | 9 | |||||||||
| Page Range: | pp. 1721-1723 | |||||||||
| DOI: | 10.1080/15548627.2020.1794356 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Publisher Statement: | “This is an Accepted Manuscript of an article published by Taylor & Francis in Autophagy on 18/07/2020, available online: http://www.tandfonline.com/10.1080/15548627.2020.1794356 | |||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||
| RIOXX Funder/Project Grant: |
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