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Echinoderms provide missing link in the evolution of PrRP/sNPF-type neuropeptide signalling

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Yañez-Guerra, Luis Alfonso, Zhong, Xingxing, Moghul, Ismail, Butts, Thomas, Zampronio, Cleidiane G., Jones, Alexandra M., Mirabeau, Olivier and Elphick, Maurice R. (2020) Echinoderms provide missing link in the evolution of PrRP/sNPF-type neuropeptide signalling. eLife, 9 . doi:10.7554/eLife.57640

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Official URL: http://dx.doi.org/10.7554/eLife.57640

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Abstract

Neuropeptide signalling systems comprising peptide ligands and cognate receptors are evolutionarily ancient regulators of physiology and behaviour. However, there are challenges associated with determination of orthology between neuropeptides in different taxa. Orthologs of vertebrate neuropeptide-Y (NPY) known as neuropeptide-F (NPF) have been identified in protostome invertebrates, whilst prolactin-releasing peptide (PrRP) and short neuropeptide-F (sNPF) have been identified as paralogs of NPY/NPF in vertebrates and protostomes, respectively. Here we investigated the occurrence of NPY/NPF/PrRP/sNPF-related signalling systems in a deuterostome invertebrate phylum – the Echinodermata. Analysis of transcriptome/genome sequence data revealed loss of NPY/NPF-type signalling, but orthologs of PrRP-type neuropeptides and sNPF/PrRP-type receptors were identified in echinoderms. Furthermore, experimental studies revealed that the PrRP-type neuropeptide pQDRSKAMQAERTGQLRRLNPRF-NH2 is a potent ligand for a sNPF/PrRP-type receptor in the starfish Asterias rubens. Our findings indicate that PrRP-type and sNPF-type signalling systems are orthologous and originated as a paralog of NPY/NPF-type signalling in Urbilateria.

Item Type: Journal Article
Subjects: Q Science > QL Zoology
Q Science > QP Physiology
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Echinodermata, Neuropeptides -- Analysis, Neuropeptide Y, Peptides -- Synthesis
Journal or Publication Title: eLife
Publisher: eLife Sciences Publications Ltd.
ISSN: 2050-084X
Official Date: 24 June 2020
Dates:
DateEvent
24 June 2020Published
12 June 2020Accepted
Date of first compliant deposit: 6 July 2020
Volume: 9
DOI: 10.7554/eLife.57640
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
BB/M00164[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/M00103[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
418612Consejo Nacional de Ciencia y Tecnologíahttp://dx.doi.org/10.13039/501100003141
RPG-2016–353Leverhulme Trusthttp://dx.doi.org/10.13039/501100000275
UNSPECIFIEDQueen Mary University of Londonhttp://dx.doi.org/10.13039/100009148
UNSPECIFIEDChina Scholarship Councilhttp://dx.doi.org/10.13039/501100004543

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