D'Elia, Lanfranco, Giaquinto, A., Cappuccio, Francesco, Iacone, Roberto, Russo, Ornella, Strazzullo, Pasquale and Galletti, Ferruccio (2020) Circulating leptin is associated with serum uric acid level and its tubular reabsorption in a sample of adult middle-aged men. Journal of Endocrinology Investigation, 43 . pp. 587-593. doi:10.1007/s40618-019-01140-4

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Abstract

Purpose
Leptin is associated with cardiovascular risk factors (e.g. hypertension, insulin resistance, kidney disease and excess body weight). Experimental studies showed that leptin might affect serum uric acid, by modulation of the uric acid excretion. However, there are few observational data on the relationship between leptin and uric acid in the general population. Therefore, the aim of the present study was to evaluate the relationship between leptin and uric acid and its excretion in a large middle-aged male general population.

Methods
A sample of 930 adult male individuals (mean age: 52 years) without therapy for high uric acid was included in the analysis (the Olivetti Heart Study).

Results
Uric acid was significantly and positively associated with blood pressure, BMI, waist circumference, insulin resistance, C-reactive protein and leptin (p < 0.01), while inversely with renal function (p = 0.01). The multivariate analysis confirmed the association between leptin and uric acid after adjustment for potential confounders (p < 0.01). After division for adiposity, this trend was confirmed separately for normal weight and excess body weight participants. Moreover, leptin was inversely associated with excretion of uric acid (p < 0.01), also in multivariate analysis (p = 0.03).

Conclusion
The results of this study indicate a positive association between circulating leptin levels and uric acid, independently of potential confounders, both in normal and excess body weight men. Furthermore, an inverse association between leptin and uric acid excretion was detected.

Item Type:	Journal Article
Subjects:	Q Science > QP Physiology R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Cardiovascular system -- Diseases , Cardiovascular system -- Diseases -- Diagnosis, Cardiovascular system -- Diseases -- Prevention, Uric acid , Uric acid -- Absorption and adsorption , Lipotropin , Leptin
Journal or Publication Title:	Journal of Endocrinology Investigation
Publisher:	Springer
ISSN:	1720-8386
Official Date:	May 2020
Dates:	Date Event May 2020 Published 5 November 2019 Available 28 October 2019 Accepted
Date of first compliant deposit:	9 July 2020
Volume:	43
Page Range:	pp. 587-593
DOI:	10.1007/s40618-019-01140-4
Status:	Peer Reviewed
Publication Status:	Published
Publisher Statement:	This is a post-peer-review, pre-copyedit version of an article published in Journal of Endocrinology Investigation. The final authenticated version is available online at: http://dx.doi.org/10.1007/s40618-019-01140-4
Access rights to Published version:	Restricted or Subscription Access

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