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Exploring precision polymers to fine-tune magnetic resonance imaging properties of iron oxide nanoparticles
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King, Aaron M., Bray, Caroline, Hall, Stephen C. L., Bear, Joseph C., Bogart, Lara K., Perrier, Sébastien and Davies, Gemma-Louise (2020) Exploring precision polymers to fine-tune magnetic resonance imaging properties of iron oxide nanoparticles. Journal of Colloid and Interface Science, 579 . pp. 401-411. doi:10.1016/j.jcis.2020.06.036
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Official URL: https://doi.org/10.1016/j.jcis.2020.06.036
Abstract
The use of bio-polymers as stabilising agents for iron oxide-based negative magnetic resonance imaging (MRI) contrast agents has become popular in recent years, however the wide polydispersity of biologically-derived and commercially available polymers limits the ability to produce truly tuneable and reproducible behaviour, a major challenge in this area. In this work, stable colloids of iron oxide nanoparticles were prepared utilising precision-engineered bio-polymer mimics, poly(2-acrylamido-2-methylpropane sodium sulfonate) (P(AMPS)) polymers, with controlled narrow polydispersity molecular weights, as templating stabilisers. In addition to producing magnetic colloids with excellent MRI contrast capabilities (r values reaching 434.2 mM s at 25 °C and 23 MHz, several times higher than similar commercial analogues), variable field relaxometry provided unexpected important insights into the dynamic environment of the hydrated materials, and hence their exceptional MRI behaviour. Thanks to the polymer's templating backbone and flexible conformation in aqueous suspension, nanocomposites appear to behave as "multi-core" clustered species, enhancing interparticle interactions whilst retaining water diffusion, boosting relaxation properties at low frequency. This clustering behaviour, evidenced by small-angle X-ray scattering, and strong relaxometric response, was fine-tuned using the well-defined molecular weight polymer species with precise iron to polymer ratios. By also showing negligible haemolytic activity, these nanocomposites exhibit considerable potential for MRI diagnostics. [Abstract copyright: Crown Copyright © 2020. Published by Elsevier Inc. All rights reserved.]
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | Q Science > QC Physics Q Science > QD Chemistry Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||||
| SWORD Depositor: | Library Publications Router | ||||||||||||
| Library of Congress Subject Headings (LCSH): | Polymers, Biopolymers, Magnetic resonance imaging, Magnetic particle imaging, Iron oxides | ||||||||||||
| Journal or Publication Title: | Journal of Colloid and Interface Science | ||||||||||||
| Publisher: | Academic Press Inc. Elsivier Science | ||||||||||||
| ISSN: | 0021-9797 | ||||||||||||
| Official Date: | 1 November 2020 | ||||||||||||
| Dates: |
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| Volume: | 579 | ||||||||||||
| Page Range: | pp. 401-411 | ||||||||||||
| DOI: | 10.1016/j.jcis.2020.06.036 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||
| RIOXX Funder/Project Grant: |
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