Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Genomic epidemiology and evolutionary dynamics of respiratory syncytial virus group B in Kilifi, Kenya, 2015-17

Tools
- Tools
+ Tools

Kamau, Everlyn, Otieno, James R., Murunga, Nickson, Oketch, John W., Ngoi, Joyce M., de Laurent, Zaydah R., Mwema, Anthony, Nyiro, Joyce U., Agoti, Charles N. and Nokes, D. James (2020) Genomic epidemiology and evolutionary dynamics of respiratory syncytial virus group B in Kilifi, Kenya, 2015-17. Virus Evolution, 6 (2). veaa050. doi:10.1093/ve/veaa050 ISSN 2057-1577.

[img]
Preview
PDF
WRAP-Genomic-epidemiology-evolutionary-dynamics-virus-Kenya-Nokes-2020.pdf - Accepted Version - Requires a PDF viewer.
Available under License Creative Commons Attribution 4.0.

Download (3371Kb) | Preview
Official URL: https://doi.org/10.1093/ve/veaa050

Request Changes to record.

Abstract

Respiratory syncytial virus (RSV) circulates worldwide, occurring seasonally in communities, and is a leading cause of acute respiratory illness in young children. There is paucity of genomic data from purposively sampled populations by which to investigate evolutionary dynamics and transmission patterns of RSV. Here we present an analysis of 295 RSV group B (RSVB) genomes from Kilifi, coastal Kenya, sampled from individuals seeking outpatient care in 9 health facilities across a defined geographical area (∼890 km2), over 2 RSV epidemics between 2015 and 2017. RSVB diversity was characterized by multiple virus introductions into the area and co-circulation of distinct genetic clusters, which transmitted and diversified locally with varying frequency. Increase in relative genetic diversity paralleled seasonal virus incidence. Importantly, we identified a cluster of viruses that emerged in the 2016/17 epidemic, carrying distinct amino-acid signatures including a novel non-synonymous change (K68Q) in antigenic site ∅ in the Fusion protein. RSVB diversity was additionally marked by signature non-synonymous substitutions that were unique to particular genomic clusters, some under diversifying selection. Our findings provide insights into recent evolutionary and epidemiological behaviors of RSV group B, and highlight possible emergence of a novel antigenic variant, which has implications on current prophylactic strategies in development.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Respiratory organs -- Diseases -- Kenya -- Kilifi, Respiratory syncytial virus -- Transmission, Respiratory syncytial virus -- Transmission -- Kenya -- Kilifi
Journal or Publication Title: Virus Evolution
Publisher: Oxford University Press (OUP)
ISSN: 2057-1577
Official Date: July 2020
Dates:
DateEvent
July 2020Published
15 July 2020Available
29 June 2020Accepted
Volume: 6
Number: 2
Article Number: veaa050
DOI: 10.1093/ve/veaa050
Status: Peer Reviewed
Publication Status: Published
Reuse Statement (publisher, data, author rights): ** Article version: AM ** From Crossref via Jisc Publications Router ** History: epub 15-07-2020; issued 15-07-2020. ** Licence for AM version of this article starting on 15-07-2020: http://creativecommons.org/licenses/by/4.0/
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 30 July 2020
Date of first compliant Open Access: 3 August 2020
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
102975Wellcome Trusthttp://dx.doi.org/10.13039/100010269
203077Wellcome Trusthttp://dx.doi.org/10.13039/100010269
DEL-15-003African Academy of Scienceshttp://dx.doi.org/10.13039/501100011858
107769/Z/10/ZWellcome Trusthttp://dx.doi.org/10.13039/100010269
UNSPECIFIEDGovernment of the United Kingdomhttp://dx.doi.org/10.13039/100013986
Related URLs:
  • http://creativecommons.org/licenses/by/4...
  • Related dataset

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us