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Spatiotemporal coordination of FGF and Shh signaling underlies the specification of myoblasts in the zebrafish embryo

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Yin, Jianmin, Lee, Raymond, Ono, Yosuke, Ingham, Philip W. and Saunders, Timothy E. (2018) Spatiotemporal coordination of FGF and Shh signaling underlies the specification of myoblasts in the zebrafish embryo. Developmental Cell, 46 (6). 735-750.e4. doi:10.1016/j.devcel.2018.08.024

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Official URL: http://dx.doi.org/10.1016/j.devcel.2018.08.024

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Abstract

Somitic cells give rise to a variety of cell types in response to Hh, BMP, and FGF signaling. Cell position within the developing zebrafish somite is highly dynamic: how, when, and where these signals specify cell fate is largely unknown. Combining four-dimensional imaging with pathway perturbations, we characterize the spatiotemporal specification and localization of somitic cells. Muscle formation is guided by highly orchestrated waves of cell specification. We find that FGF directly and indirectly controls the differentiation of fast and slow-twitch muscle lineages, respectively. FGF signaling imposes tight temporal control on Shh induction of slow muscles by regulating the time at which fast-twitch progenitors displace slow-twitch progenitors from contacting the Shh-secreting notochord. Further, we find a reciprocal regulation of fast and slow muscle differentiation, morphogenesis, and migration. In conclusion, robust cell fate determination in the developing somite requires precise spatiotemporal coordination between distinct cell lineages and signaling pathways.

Item Type: Journal Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology
Faculty of Medicine > Warwick Medical School > Biomedical Sciences
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Zebra danio -- Genetics, Zebra danios as laboratory animals, Myogenesis
Journal or Publication Title: Developmental Cell
Publisher: Cell Press
ISSN: 1534-5807
Official Date: 24 September 2018
Dates:
DateEvent
24 September 2018Published
23 August 2018Accepted
Date of first compliant deposit: 29 July 2020
Volume: 46
Number: 6
Page Range: 735-750.e4
DOI: 10.1016/j.devcel.2018.08.024
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Description:

Free access/open archive

RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
NRF2012NRF-NRFF001-094National Research Foundation Singaporehttp://dx.doi.org/10.13039/501100001381

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