UNSPECIFIED (1999) Mode of action of VegT in mesoderm and endoderm formation. DEVELOPMENT, 126 (21). pp. 4903-4911. ISSN 0950-1991

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Abstract

mRNA encoding the T-box transcription factor VegT is located throughout the vegetal pole of the Xenopus egg and is believed to play an important part in endoderm and mesoderm formation. We find that VegT generates endoderm both by cell-autonomous action ana by generating TGF-beta family signals, the latter being entirely responsible for its mesoderm-inducing activity Signalling molecules induced cell-autonomously by VegT include derriere, Xnr4 and activin B. Xnr1 and Xnr2 are also induced, but primarily in a non-autonomous manner. All of these signalling molecules are found in the blastula and gastrula vegetal pole and induce both endoderm and mesoderm in the animal cap assay, and hence are good candidates both for the endogenous zygotic mesoderm-inducing signal and for reinforcing the vegetal expression of endoderm markers.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH301 Biology
Journal or Publication Title:	DEVELOPMENT
Publisher:	COMPANY OF BIOLOGISTS LTD
ISSN:	0950-1991
Date:	November 1999
Volume:	126
Number:	21
Number of Pages:	9
Page Range:	pp. 4903-4911
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/13971

Data sourced from Thomson Reuters' Web of Knowledge

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