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Extensive signal integration by the phytohormone protein network
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(2020) Extensive signal integration by the phytohormone protein network. Nature, 583 (7815). pp. 271-276. doi:10.1038/s41586-020-2460-0 ISSN 0028-0836.
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WRAP-Extensive-signal-integration-phytohormone-protein-network-Bassel-2020 (1).pdf - Accepted Version - Requires a PDF viewer. Download (1566Kb) | Preview |
Official URL: http://dx.doi.org/10.1038/s41586-020-2460-0
Abstract
Plant hormones coordinate responses to environmental cues with developmental programs1, and are fundamental for stress resilience and agronomic yield2. The core signalling pathways underlying the effects of phytohormones have been elucidated by genetic screens and hypothesis-driven approaches, and extended by interactome studies of select pathways3. However, fundamental questions remain about how information from different pathways is integrated. Genetically, most phenotypes seem to be regulated by several hormones, but transcriptional profiling suggests that hormones trigger largely exclusive transcriptional programs4. We hypothesized that protein–protein interactions have an important role in phytohormone signal integration. Here, we experimentally generated a systems-level map of the Arabidopsis phytohormone signalling network, consisting of more than 2,000 binary protein–protein interactions. In the highly interconnected network, we identify pathway communities and hundreds of previously unknown pathway contacts that represent potential points of crosstalk. Functional validation of candidates in seven hormone pathways reveals new functions for 74% of tested proteins in 84% of candidate interactions, and indicates that a large majority of signalling proteins function pleiotropically in several pathways. Moreover, we identify several hundred largely small-molecule-dependent interactions of hormone receptors. Comparison with previous reports suggests that noncanonical and nontranscription-mediated receptor signalling is more common than hitherto appreciated.
| Item Type: | Journal Article | |||||||||||||||
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| Subjects: | Q Science > QK Botany S Agriculture > SB Plant culture |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||||||||
| Library of Congress Subject Headings (LCSH): | Plant hormones , Plant hormones -- Receptors, Protein-protein interactions | |||||||||||||||
| Journal or Publication Title: | Nature | |||||||||||||||
| Publisher: | Nature Publishing | |||||||||||||||
| ISSN: | 0028-0836 | |||||||||||||||
| Official Date: | 9 July 2020 | |||||||||||||||
| Dates: |
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| Volume: | 583 | |||||||||||||||
| Number: | 7815 | |||||||||||||||
| Page Range: | pp. 271-276 | |||||||||||||||
| DOI: | 10.1038/s41586-020-2460-0 | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
| Date of first compliant deposit: | 29 July 2020 | |||||||||||||||
| Date of first compliant Open Access: | 1 January 2021 | |||||||||||||||
| RIOXX Funder/Project Grant: |
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