Rees, Karen, Takeda, Andrea, Martin, Nicole, Ellis, Leila, Wijesekara, Dilini, Vepa, Abhinav, Das, Archik, Hartley, Louise and Stranges, Saverio (2020) Mediterranean-style diet for the primary and secondary prevention of cardiovascular disease : a Cochrane review. Global Heart, 15 (1). 56. doi:10.5334/gh.853 ISSN 2211-8179.

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Abstract

Background: Diet plays a major role in cardiovascular disease (CVD) risk.

Objectives: To determine the effectiveness of a Mediterranean-style diet for the primary and secondary prevention of CVD.

Methods: We searched for randomised controlled trials (RCTs) of Mediterranean-style diets in healthy adults and those at increased risk of CVD (primary prevention) and with established CVD (secondary prevention).

Results: Thirty RCTs were included, 22 in primary prevention and eight in secondary prevention. Clinical endpoints were reported in two trials where there was moderate quality evidence for a reduction in strokes for primary prevention, and low quality evidence for a reduction in total and CVD mortality in secondary prevention. We found moderate quality evidence of improvement in CVD risk factors for primary prevention and low quality evidence of little or no effect in secondary prevention.

Conclusions: There is still some uncertainty regarding the effects of a Mediterranean-style diet in CVD prevention.

Item Type:	Journal Article
Subjects:	R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology T Technology > TX Home economics
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Diet -- Mediterranean Region, Cooking, Mediterranean -- Health aspects, Heart -- Diseases -- Diet therapy -- Recipes, Cardiovascular system -- Diseases -- Prevention, Nutrition, Heart -- Diseases -- Nutritional aspects
Journal or Publication Title:	Global Heart
Publisher:	Elsevier
ISSN:	2211-8179
Official Date:	12 August 2020
Dates:	Date Event 12 August 2020 Published 29 July 2020 Accepted
Volume:	15
Number:	1
Article Number:	56
DOI:	10.5334/gh.853
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)
Date of first compliant deposit:	4 August 2020
Date of first compliant Open Access:	14 August 2020
RIOXX Funder/Project Grant:	Project/Grant ID RIOXX Funder Name Funder ID Cochrane Infrastructure [NIHR] National Institute for Health Research http://dx.doi.org/10.13039/501100000272
Related URLs:	Publisher

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