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Multi-arm star shaped glycopolymers with precisely controlled core size and arm length
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Monaco, Alessandra, Beyer, Valentin P., Napier, Richard and Becer, C. Remzi (2020) Multi-arm star shaped glycopolymers with precisely controlled core size and arm length. Biomacromolecules, 21 (9). pp. 3736-3744. doi:10.1021/acs.biomac.0c00838 ISSN 1525-7797.
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WRAP-Multi-arm-star-shaped-glycopolymers-precisely-core-length-Becer-2020.pdf - Accepted Version - Requires a PDF viewer. Download (1900Kb) | Preview |
Official URL: http://dx.doi.org/10.1021/acs.biomac.0c00838
Abstract
Star shaped glycopolymers provide very high binding activities towards lectins. However, straightforward synthesis method for the preparation of multi-arm glycopolymers in a one-pot approach has been challenging. Herein, we report a rapid synthesis of well-defined multi-arm glycopolymers via Cu(0)-mediated reversible deactivation radical polymerisation in aqueous media. D-Mannose acrylamide has been homo- and copolymerized with NIPAM to provide linear arms and then core crosslinked with a bisacrylamide monomer. Thus, the arm length and core size of multi-arm glycopolymers were tuned. Moreover, the stability of multi-arm glycopolymers was investigated and degradation reactions under acidic or basic conditions were observed. The binding activities of the obtained multi-arm glycopolymers with mannose-specific human lectins, DC-SIGN and MBL, were investigated via surface plasmon resonance spectroscopy. Finally, the encapsulation ability of multi-arm glycopolymers was examined using DHA and Saquinavir below and above the LCST of P(NIPAM).
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
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| Library of Congress Subject Headings (LCSH): | Copolymers -- Synthesis, Lectins | ||||||||
| Journal or Publication Title: | Biomacromolecules | ||||||||
| Publisher: | American Chemical Society | ||||||||
| ISSN: | 1525-7797 | ||||||||
| Official Date: | 14 September 2020 | ||||||||
| Dates: |
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| Volume: | 21 | ||||||||
| Number: | 9 | ||||||||
| Page Range: | pp. 3736-3744 | ||||||||
| DOI: | 10.1021/acs.biomac.0c00838 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Reuse Statement (publisher, data, author rights): | “This document is the Accepted Manuscript version of a Published Work that appeared in final form in Biomacromolecules, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].” | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Copyright Holders: | © 2020 American Chemical Society | ||||||||
| Date of first compliant deposit: | 5 August 2020 | ||||||||
| Date of first compliant Open Access: | 30 July 2021 |
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