Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Multi-arm star shaped glycopolymers with precisely controlled core size and arm length

Tools
- Tools
+ Tools

Monaco, Alessandra, Beyer, Valentin P., Napier, Richard and Becer, C. Remzi (2020) Multi-arm star shaped glycopolymers with precisely controlled core size and arm length. Biomacromolecules, 21 (9). pp. 3736-3744. doi:10.1021/acs.biomac.0c00838

[img] PDF
WRAP-Multi-arm-star-shaped-glycopolymers-precisely-core-length-Becer-2020.pdf - Accepted Version
Embargoed item. Restricted access to Repository staff only until 30 July 2021. Contact author directly, specifying your specific needs. - Requires a PDF viewer.

Download (1900Kb)
Official URL: http://dx.doi.org/10.1021/acs.biomac.0c00838

Request Changes to record.

Abstract

Star shaped glycopolymers provide very high binding activities towards lectins. However, straightforward synthesis method for the preparation of multi-arm glycopolymers in a one-pot approach has been challenging. Herein, we report a rapid synthesis of well-defined multi-arm glycopolymers via Cu(0)-mediated reversible deactivation radical polymerisation in aqueous media. D-Mannose acrylamide has been homo- and copolymerized with NIPAM to provide linear arms and then core crosslinked with a bisacrylamide monomer. Thus, the arm length and core size of multi-arm glycopolymers were tuned. Moreover, the stability of multi-arm glycopolymers was investigated and degradation reactions under acidic or basic conditions were observed. The binding activities of the obtained multi-arm glycopolymers with mannose-specific human lectins, DC-SIGN and MBL, were investigated via surface plasmon resonance spectroscopy. Finally, the encapsulation ability of multi-arm glycopolymers was examined using DHA and Saquinavir below and above the LCST of P(NIPAM).

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Q Science > QP Physiology
Divisions: Faculty of Science > Chemistry
Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Copolymers -- Synthesis, Lectins
Journal or Publication Title: Biomacromolecules
Publisher: American Chemical Society
ISSN: 1525-7797
Official Date: 14 September 2020
Dates:
DateEvent
14 September 2020Published
30 July 2020Available
30 July 2020Accepted
Date of first compliant deposit: 5 August 2020
Volume: 21
Number: 9
Page Range: pp. 3736-3744
DOI: 10.1021/acs.biomac.0c00838
Status: Peer Reviewed
Publication Status: Published
Publisher Statement: “This document is the Accepted Manuscript version of a Published Work that appeared in final form in Biomacromolecules, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].”
Access rights to Published version: Restricted or Subscription Access
Copyright Holders: © 2020 American Chemical Society

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us