Zanders, Edward Douglas (1976) Mitochondrial genes and their expression in Saccharomyces cerevisiae. PhD thesis, University of Warwick.

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Abstract

The more traditional interest in mitochondria as energy conserving organelles has in recent years been rivalled by studies related to membrane biogenesis. An extensive literature has shown that mitochondria are semi-autonomous with a system for the expression of their own genome in pleiotropy with nuclear genes and cytoplasmic protein synthesis. The presence of cytoplasmic genes in mitochondria provides a physical basis for the long observed phenomenon of maternal inheritance or "non-Mendelian" genetics, (1) in which the cytoplasmic phenotype is derived from the maternal parent only. This has been demonstrated in fungi, (2) amphibians, (3) and, more recently, in mammals (4, 5). The synthesis of mitochondrial membranes from pre-existing structures, as opposed to de novo synthesis, is in accordance with the partial genetic autonomy of these organelles. (6, 7). To this end, mitochondria possess DNA, RNA and a protein synthesis system.

Item Type:	Thesis (PhD)
Subjects:	Q Science > QH Natural history Q Science > QK Botany Q Science > QP Physiology
Library of Congress Subject Headings (LCSH):	Mitochondrial DNA, Mitochondria, Saccharomyces cerevisiae
Official Date:	September 1976
Dates:	Date Event September 1976 UNSPECIFIED
Institution:	University of Warwick
Theses Department:	Department of Molecular Sciences
Thesis Type:	PhD
Publication Status:	Unpublished
Supervisor(s)/Advisor:	Griffiths, D. E.
Sponsors:	Science Research Council (Great Britain)
Extent:	77, [6] leaves : illustrations
Language:	eng

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