Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Pre-analytical and analytical variables that influence urinary volatile organic compound measurements

Tools
- Tools
+ Tools

McFarlane, Michael J., Mozdiak, Ella , Daulton, Emma, Arasaradnam, Ramesh P., Covington, James A. and Nwokolo, Chuka U. (2020) Pre-analytical and analytical variables that influence urinary volatile organic compound measurements. PLoS One, 15 (7). e0236591. doi:10.1371/journal.pone.0236591 ISSN 1932-6203.

[img]
Preview
PDF
WRAP-Pre-analytical-influence-urinary-volatile-organic-measurements-Covington-2020.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution 4.0.

Download (3592Kb) | Preview
Official URL: https://doi.org/10.1371/journal.pone.0236591

Request Changes to record.

Abstract

There has been rapidly accelerating interest in the utilization of volatile organic compounds (VOCs) as non-invasive methods for rapid point-of-care medical diagnostics. There is widespread variation in analytical methods and protocols, with little understanding of the effects of sample storage on VOC profiles. This study aimed to determine the effects on VOC profiles of different storage times, at room temperature, prior to freezing, of sealed urine samples from healthy individuals. Analysis using Field Asymmetric Ion Motility Spectrometry (FAIMS) determined the alterations in VOC and total ion count profiles as a result of increasing room temperature storage times. Results indicated that increasing exposure time to room temperature prior to freezing had a threefold effect. Firstly, increased urinary VOC profile variability, with a plateau phase between 12 and 48 hours, before further degradation. Secondly, an increase in total ion count with time exposed to room temperature. Finally, a deterioration in VOCs with each sample run during the analysis process. This provides new insight into the effect of storage of urine samples for VOC analysis using FAIMS technology. Results of this study provide a recommendation for a 12-hour maximum duration at room temperature prior to storage.

Item Type: Journal Article
Subjects: T Technology > TD Environmental technology. Sanitary engineering
Divisions: Faculty of Science, Engineering and Medicine > Engineering > Engineering
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Volatile organic compounds, Biochemical markers, Urine
Journal or Publication Title: PLoS One
Publisher: Public Library of Science
ISSN: 1932-6203
Official Date: 31 July 2020
Dates:
DateEvent
31 July 2020Published
8 July 2020Accepted
Volume: 15
Number: 7
Article Number: e0236591
DOI: 10.1371/journal.pone.0236591
Status: Peer Reviewed
Publication Status: Published
Reuse Statement (publisher, data, author rights): ** From PubMed via Jisc Publications Router ** History: received 24-03-2020; accepted 08-07-2020.
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 18 September 2020
Date of first compliant Open Access: 22 September 2020

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us