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Evasion of host defenses by intracellular Staphylococcus aureus
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Watkins, Kate E. and Unnikrishnan, Meera (2020) Evasion of host defenses by intracellular Staphylococcus aureus. In: Advanced Applied Microbiology. San Diego: Academic Press, pp. 105-141. ISBN 9780128207062
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Official URL: https://doi.org/10.1016/bs.aambs.2020.05.001
Abstract
Staphylococcus aureus is one of the leading causes of hospital and community-acquired infections worldwide. The increasing occurrence of antibiotic resistant strains and the high rates of recurrent staphylococcal infections have placed several treatment challenges on healthcare systems. In recent years, it has become evident that S. aureus is a facultative intracellular pathogen, able to invade and survive in a range of cell types. The ability to survive intracellularly provides this pathogen with yet another way to evade antibiotics and immune responses during infection. Intracellular S. aureus have been strongly linked to several recurrent infections, including severe bone infections and septicemias. S. aureus is armed with an array of virulence factors as well as an intricate network of regulators that enable it to survive, replicate and escape from a number of immune and nonimmune host cells. It is able to successfully manipulate host cell pathways and use it as a niche to multiply, disseminate, as well as persist during an infection. This bacterium is also known to adapt to the intracellular environment by forming small colony variants, which are metabolically inactive. In this review we will discuss the clinical evidence, the molecular pathways involved in S. aureus intracellular persistence, and new treatment strategies for targeting intracellular S. aureus. [Abstract copyright: © 2020 Elsevier Inc. All rights reserved.]
Item Type: | Book Item | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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SWORD Depositor: | Library Publications Router | ||||
Journal or Publication Title: | Advances in Applied Microbiology | ||||
Publisher: | Academic Press | ||||
Place of Publication: | San Diego | ||||
ISBN: | 9780128207062 | ||||
ISSN: | 0065-2164 | ||||
Book Title: | Advanced Applied Microbiology | ||||
Official Date: | 27 May 2020 | ||||
Dates: |
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Volume: | 112 | ||||
Page Range: | pp. 105-141 | ||||
DOI: | 10.1016/bs.aambs.2020.05.001 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Copyright Holders: | © 2020 Elsevier Inc. All rights reserved. | ||||
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