Markov Chain Monte Carlo analysis of human Y-chromosome microsatellites provides evidence of biased mutation
UNSPECIFIED. (1999) Markov Chain Monte Carlo analysis of human Y-chromosome microsatellites provides evidence of biased mutation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 96 (21). pp. 11916-11921. ISSN 0027-8424Full text not available from this repository.
We describe a Markov Chain Monte Carlo analysis of five human Y-chromosome microsatellite polymorphisms based on samples from five diverse populations. Our analysis provides strong evidence for mutational bias favoring increase in length at all loci. Estimates of population coalescent times and population size from our two largest samples, one African and one European, suggest that the African population is older but smaller and that the English East Anglian population has undergone significant expansion, being larger but younger, We conclude that Markov Chain Monte Carlo analysis of microsatellite haplotypes can uncover information not apparent when the microsatellites are considered independently. Incorporation of population size as a variable should allow us to estimate the timing and magnitude of major historical population trends.
|Item Type:||Journal Article|
|Journal or Publication Title:||PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA|
|Publisher:||NATL ACAD SCIENCES|
|Date:||12 October 1999|
|Number of Pages:||6|
|Page Range:||pp. 11916-11921|
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