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Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease
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Baker, Adam R., Fernandez da Silva, Nancy, Quinn, David W., Harte, A. L. (Alison L.), Pagano, Domenico, Bonser, Robert S., Kumar, Sudhesh and McTernan, P. G. (Philip G.) (2006) Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease. Cardiovascular Diabetology, Vol.5 (No.1). doi:10.1186/1475-2840-5-1 ISSN 1475-2840.
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Official URL: http://dx.doi.org/10.1186/1475-2840-5-1
Abstract
Introduction: Inflammation contributes to cardiovascular disease and is exacerbated with
increased adiposity, particularly omental adiposity; however, the role of epicardial fat is poorly
understood.
Methods: For these studies the expression of inflammatory markers was assessed in epicardial fat
biopsies from coronary artery bypass grafting (CABG) patients using quantitative RT-PCR. Further,
the effects of chronic medications, including statins, as well as peri-operative glucose, insulin and
potassium infusion, on gene expression were also assessed. Circulating resistin, CRP, adiponectin
and leptin levels were determined to assess inflammation.
Results: The expression of adiponectin, resistin and other adipocytokine mRNAs were
comparable to that in omental fat. Epicardial CD45 expression was significantly higher than control
depots (p < 0.01) indicating significant infiltration of macrophages. Statin treated patients showed
significantly lower epicardial expression of IL-6 mRNA, in comparison with the control abdominal
depots (p < 0.001). The serum profile of CABG patients showed significantly higher levels of both
CRP (control: 1.28 ± 1.57 μg/mL vs CABG: 9.11 ± 15.7 μg/mL; p < 0.001) and resistin (control:
10.53 ± 0.81 ng/mL vs CABG: 16.8 ± 1.69 ng/mL; p < 0.01) and significantly lower levels of
adiponectin (control: 29.1 ± 14.8 μg/mL vs CABG: 11.9 ± 6.0 μg/mL; p < 0.05) when compared to
BMI matched controls.
Conclusion: Epicardial and omental fat exhibit a broadly comparable pathogenic mRNA profile,
this may arise in part from macrophage infiltration into the epicardial fat. This study highlights that
chronic inflammation occurs locally as well as systemically potentially contributing further to the
pathogenesis of coronary artery disease.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RC Internal medicine | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Library of Congress Subject Headings (LCSH): | Coronary heart disease, Inflammation | ||||
Journal or Publication Title: | Cardiovascular Diabetology | ||||
Publisher: | Biomed central | ||||
ISSN: | 1475-2840 | ||||
Official Date: | 13 January 2006 | ||||
Dates: |
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Volume: | Vol.5 | ||||
Number: | No.1 | ||||
DOI: | 10.1186/1475-2840-5-1 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Description: | Final version (published as open access). |
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