UNSPECIFIED. (1999) The extrafollicular-to-follicular transition of human B lymphocytes: induction of functional globotriaosylceramide (CD77) on high threshold occupancy of CD40. EUROPEAN JOURNAL OF IMMUNOLOGY, 29 (10). pp. 3236-3244. ISSN 0014-2980

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Abstract

Amongst lymphocytes, expression of CD77 (globotriaosylceramide, Gb3) is exclusive to B cells of the germinal center (GC). Its acquisition by extrafollicular B cells may thus herald their commitment to a follicular response. Here we show that high threshold occupancy of CD40 by its cognate ligand (CD40L) promotes rapid induction of CD77 expression in non-GC (CD38(lo)) B cells. The kinetics of CD77 acquisition mirrored those of GC-related markers CD95 and CD86 but contrasted with the more delayed increase in CD38 expression. Induction of CD77 was not a simple consequence of cell cycle entry: other conditions of stimulation equally capable of driving proliferation failed to promote CD77 expression. CD77 was functional in that cells were now sensitive to Verotoxin-l, an Escherichia coil-derived ligand of Gb3. These data indicate that acquisition by extrafollicular B cells of CD77 results from high threshold occupancy of CD40, a situation that should be reached physiologically only once a critical level of T cell priming has been achieved.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology > QR180 Immunology
Journal or Publication Title:	EUROPEAN JOURNAL OF IMMUNOLOGY
Publisher:	WILEY-V C H VERLAG GMBH
ISSN:	0014-2980
Date:	October 1999
Volume:	29
Number:	10
Number of Pages:	9
Page Range:	pp. 3236-3244
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/14107

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