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Hippocampal subfield volumes are nonspecifically reduced in premature‐born adults
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Hedderich, Dennis M., Avram, Mihai, Menegaux, Aurore, Nuttall, Rachel, Zimmermann, Juliana, Schneider, Sebastian C., Schmitz‐Koep, Benita, Daamen, Marcel, Scheef, Lukas, Boecker, Henning, Zimmer, Claus, Baumann, Nicole, Bartmann, Peter, Wolke, Dieter, Bäuml, Josef G. and Sorg, Christian (2020) Hippocampal subfield volumes are nonspecifically reduced in premature‐born adults. Human Brain Mapping, 41 (18). pp. 5215-5227. doi:10.1002/hbm.25187 ISSN 1065-9471.
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Official URL: https://doi.org/10.1002/hbm.25187
Abstract
Reduced global hippocampus volumes have been demonstrated in premature‐born individuals, from newborns to adults; however, it is unknown whether hippocampus subfield (HCSF) volumes are differentially affected by premature birth and how relevant they are for cognitive performance. To address these questions, we investigated magnetic resonance imaging (MRI)‐derived HCSF volumes in very premature‐born adults, and related them with general cognitive performance in adulthood. We assessed 103 very premature‐born (gestational age [GA] <32 weeks and/or birth weight <1,500 g) and 109 term‐born individuals with cognitive testing and structural MRI at 26 years of age. HCSFs were automatically segmented based on three‐dimensional T1‐ and T2‐weighted sequences and studied both individually and grouped into three functional units, namely hippocampus proper (HP), subicular complex (SC), and dentate gyrus (DG). Cognitive performance was measured using the Wechsler‐Adult‐Intelligence‐Scale (full‐scale intelligence quotient [FS‐IQ]) at 26 years. We observed bilateral volume reductions for almost all HCSF volumes in premature‐born adults and associations with GA and neonatal treatment intensity but not birth weight. Left‐sided HP, SC, and DG volumes were associated with adult FS‐IQ. Furthermore, left DG volume was a mediator of the association between GA and adult FS‐IQ in premature‐born individuals. Results demonstrate nonspecifically reduced HCSF volumes in premature‐born adults; but specific associations with cognitive outcome highlight the importance of the left DG. Data suggest that specific interventions toward hippocampus function might be promising to lower adverse cognitive effects of prematurity.
Item Type: | Journal Article | |||||||||||||||||||||
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Subjects: | B Philosophy. Psychology. Religion > BF Psychology Q Science > QP Physiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Science > Psychology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Premature infants -- Development, Hippocampus (Brain) -- Physiology, Intellect | |||||||||||||||||||||
Journal or Publication Title: | Human Brain Mapping | |||||||||||||||||||||
Publisher: | John Wiley and Sons | |||||||||||||||||||||
ISSN: | 1065-9471 | |||||||||||||||||||||
Official Date: | 15 December 2020 | |||||||||||||||||||||
Dates: |
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Volume: | 41 | |||||||||||||||||||||
Number: | 18 | |||||||||||||||||||||
Page Range: | pp. 5215-5227 | |||||||||||||||||||||
DOI: | 10.1002/hbm.25187 | |||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||
Date of first compliant deposit: | 9 September 2020 | |||||||||||||||||||||
Date of first compliant Open Access: | 10 September 2020 | |||||||||||||||||||||
RIOXX Funder/Project Grant: |
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