Astrocytes rather than neurones mediate interleukin-1 beta dependent nitric oxide and superoxide radical release in primary hypothalamic rat cell cultures
UNSPECIFIED. (1999) Astrocytes rather than neurones mediate interleukin-1 beta dependent nitric oxide and superoxide radical release in primary hypothalamic rat cell cultures. NEUROSCIENCE LETTERS, 273 (1). pp. 57-60. ISSN 0304-3940Full text not available from this repository.
The cellular sources of nitric oxide in the hypothalamus are thought to be 'NOergic' neurones. Using free radical electrochemical sensors we investigated nitric oxide and superoxide radical release in primary hypothalamic cell cultures. We present evidence that under interteukin-1 beta (IL-1 beta) stimulation hypothalamic astrocytes rather than neurones release nitric oxide. Under L-arginine deprivation and IL-1 beta stimulation a concentration-dependent release of superoxide was also observed, which was inhibited in the presence of nitric oxide synthase inhibitor nitro-L-arginine-methyl-ester. These findings support the hypothesis that the balance between nitric oxide and superoxide may be of vital importance in hypothalamic pathophysiology. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry|
|Journal or Publication Title:||NEUROSCIENCE LETTERS|
|Publisher:||ELSEVIER SCI IRELAND LTD|
|Date:||24 September 1999|
|Number of Pages:||4|
|Page Range:||pp. 57-60|
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