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Increased migratory and homing abilities of neural and mesenchymal stem cell populations by transient cell modifications : preclinical progress and clinical relevanc
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Boltze, Johannes, Didwischus, Nadine, Li, Shengcai, Jolkkonen, Jukka and Taguchi, Akihiko (2020) Increased migratory and homing abilities of neural and mesenchymal stem cell populations by transient cell modifications : preclinical progress and clinical relevanc. EBioMedicine, 60 . 103022. doi:10.1016/j.ebiom.2020.103022
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Official URL: https://doi.org/10.1016/j.ebiom.2020.103022
Abstract
Cell-based treatments of central nervous system (CNS) disorders are an emerging paradigm in experimental medicine. Given the anatomical and functional complexity of the mammalian brain, the tempting concept of simply replacing lost or critically affected brain tissue by stem cell transplants appeared difficult to realise. Therapeutic approaches now try to support endogenous regeneration and reorganisation, as well as to prevent secondary damage. This is achieved by paracrine and other so-called bystander effects. Preclinical research revealed a broad spectrum of such mechanisms for two of the most frequently investigated cell populations: mesenchymal stem cells (MSCs) and neural stem cells (NSCs). Although therapeutically relevant systemic effects of MSC and NSC transplantation have been identified, targeted delivery of cells to the brain tissue is considered important to achieve an optimal outcome in CNS disorders.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QH Natural history R Medicine > RB Pathology R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||||
| Library of Congress Subject Headings (LCSH): | Cellular therapy , Gene therapy, Central nervous system -- Diseases, Cell metabolism , Mesenchymal stem cells , Mesenchymal stem cells -- Differentiation, Neural stem cells , Neural stem cells -- Transplantation | ||||||||
| Journal or Publication Title: | EBioMedicine | ||||||||
| Publisher: | Elsevier BV | ||||||||
| ISSN: | 2352-3964 | ||||||||
| Official Date: | 1 October 2020 | ||||||||
| Dates: |
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| Volume: | 60 | ||||||||
| Article Number: | 103022 | ||||||||
| DOI: | 10.1016/j.ebiom.2020.103022 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access | ||||||||
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