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The Arabidopsis PHD-finger protein EDM2 has multiple roles in balancing NLR immune receptor gene expression

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Lai, Yan, Lu, Xueqing Maggie, Daron, Josquin, Pan, Songqin, Wang, Jianqiang, Wang, Wei, Tsuchiya, Tokuji, Holub, E. B., McDowell, John M., Slotkin, R. Keith, Le Roch, Karine G. and Eulgem, Thomas (2020) The Arabidopsis PHD-finger protein EDM2 has multiple roles in balancing NLR immune receptor gene expression. PLoS Genetics, 16 (9). e1008993. doi:10.1371/journal.pgen.1008993

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Official URL: http://dx.doi.org/10.1371/journal.pgen.1008993

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Abstract

Plant NLR-type receptors serve as sensitive triggers of host immunity. Their expression has to be well-balanced, due to their interference with various cellular processes and dose-dependency of their defense-inducing activity. A genetic “arms race” with fast-evolving pathogenic microbes requires plants to constantly innovate their NLR repertoires. We previously showed that insertion of the COPIA-R7 retrotransposon into RPP7 co-opted the epigenetic transposon silencing signal H3K9me2 to a new function promoting expression of this Arabidopsis thaliana NLR gene. Recruitment of the histone binding protein EDM2 to COPIA-R7-associated H3K9me2 is required for optimal expression of RPP7. By profiling of genome-wide effects of EDM2, we now uncovered additional examples illustrating effects of transposons on NLR gene expression, strongly suggesting that these mobile elements can play critical roles in the rapid evolution of plant NLR genes by providing the “raw material” for gene expression mechanisms. We further found EDM2 to have a global role in NLR expression control. Besides serving as a positive regulator of RPP7 and a small number of other NLR genes, EDM2 acts as a suppressor of a multitude of additional NLR genes. We speculate that the dual functionality of EDM2 in NLR expression control arose from the need to compensate for fitness penalties caused by high expression of some NLR genes by suppression of others. Moreover, we are providing new insights into functional relationships of EDM2 with its interaction partner, the RNA binding protein EDM3/AIPP1, and its target gene IBM1, encoding an H3K9-demethylase.

Item Type: Journal Article
Subjects: Q Science > QK Botany
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Plant genetic regulation, Arabidopsis thaliana -- Genetic aspects, Plant genetics, Plant gene expression
Journal or Publication Title: PLoS Genetics
Publisher: Public Library of Science
ISSN: 1553-7390
Official Date: 14 September 2020
Dates:
DateEvent
14 September 2020Published
14 July 2020Accepted
Date of first compliant deposit: 25 September 2020
Volume: 16
Number: 9
Article Number: e1008993
DOI: 10.1371/journal.pgen.1008993
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
MCB-1330905 National Science Foundationhttp://dx.doi.org/10.13039/501100008982
IOS-1457329 National Science Foundationhttp://dx.doi.org/10.13039/501100008982
UNSPECIFIEDChina Scholarship Councilhttp://dx.doi.org/10.13039/501100004543
ARF20170938823Fondation pour la Recherche MédicaleUNSPECIFIED
METHYVIREVOL[ERC] Horizon 2020 Framework Programmehttp://dx.doi.org/10.13039/100010661

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