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The SARS-COV-2 spike protein binds sialic acids and enables rapid detection in a lateral flow point of care diagnostic device

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Baker, Alexander, Richards, Sarah-Jane, Guy, Collette S., Congdon, Thomas R., Hasan, Muhammad, Zwetsloot, Alexander J., Gallo, Angelo, Lewandowski, Józef R., Stansfeld, Phillip J., Straube, Anne, Walker, Marc, Chessa, Simona, Pergolizzi, Giulia, Dedola, Simone, Field, Robert A. and Gibson, Matthew I. (2020) The SARS-COV-2 spike protein binds sialic acids and enables rapid detection in a lateral flow point of care diagnostic device. ACS Central Science, 6 (11). pp. 2046-2052. doi:10.1021/acscentsci.0c00855

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Official URL: https://doi.org/10.1021/acscentsci.0c00855

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Abstract

There is an urgent need to understand the behavior of the novel coronavirus (SARS-COV-2), which is the causative agent of COVID-19, and to develop point-of-care diagnostics. Here, a glyconanoparticle platform is used to discover that N-acetyl neuraminic acid has affinity toward the SARS-COV-2 spike glycoprotein, demonstrating its glycan-binding function. Optimization of the particle size and coating enabled detection of the spike glycoprotein in lateral flow and showed selectivity over the SARS-COV-1 spike protein. Using a virus-like particle and a pseudotyped lentivirus model, paper-based lateral flow detection was demonstrated in under 30 min, showing the potential of this system as a low-cost detection platform.

Item Type: Journal Article
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RC Internal medicine
Divisions: Faculty of Science > Chemistry
Faculty of Science > Life Sciences (2010- )
Faculty of Science > Physics
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): COVID-19 (Disease) -- Diagnosis, Point-of-care testing, Glycoproteins, Sialic acids
Journal or Publication Title: ACS Central Science
Publisher: ACS
ISSN: 2374-7951
Official Date: 25 November 2020
Dates:
DateEvent
25 November 2020Published
22 September 2020Available
11 September 2020Accepted
Date of first compliant deposit: 30 September 2020
Volume: 6
Number: 11
Page Range: pp. 2046-2052
DOI: 10.1021/acscentsci.0c00855
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Copyright Holders: Copyright © 2020 American Chemical Society
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
638661European Research Councilhttp://dx.doi.org/10.13039/501100000781
Industry Fellowship 191037Royal Societyhttp://dx.doi.org/10.13039/501100000288
BB/M01116X/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
EP/R511808/1[EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
BB/S506783/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
MR/N014294/1[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
200870/Z/16/ZWellcome Trusthttp://dx.doi.org/10.13039/100010269
RPG-2019-087Leverhulme Trusthttp://dx.doi.org/10.13039/501100000275
208361/Z/17/ZWellcome Trusthttp://dx.doi.org/10.13039/100010269
MR/S009213/1[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
BB/P01948X/1 [BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/R002517/1 [BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/S003339/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268

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