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Modelling treatment strategies to inform Yaws eradication

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Holmes, Alexander, Tildesley, Michael J., Solomon, Anthony W., Mabey, David C. W., Sokana, Oliver, Marks, Michael and Dyson, Louise (2020) Modelling treatment strategies to inform Yaws eradication. Emerging Infectious Diseases , 26 (11). pp. 2685-2693. doi:10.3201/eid2611.191491

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Official URL: https://dx.doi.org/10.3201/eid2611.191491

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Abstract

Yaws is a neglected tropical disease targeted for eradication by 2030. To achieve eradication, finding and treating asymptomatic infections as well as clinical cases is crucial. The proposed plan, the Morges strategy, involves rounds of total community treatment (i.e., treating the whole population) and total targeted treatment (TTT) (i.e., treating clinical cases and contacts). However, modeling and empirical work suggests asymptomatic infections often are not found in the same households as clinical cases, reducing the utility of household-based contact tracing for a TTT strategy. We use a model fitted to data from the Solomon Islands to predict the likelihood of elimination of transmission under different intervention schemes and levels of systematic nontreatment resulting from the intervention. Our results indicate that implementing additional treatment rounds through total community treatment is more effective than conducting additional rounds of treatment of at-risk persons through TTT.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine
Divisions: Faculty of Science > Life Sciences (2010- )
Faculty of Science > Mathematics
Library of Congress Subject Headings (LCSH): Yaws , Yaws -- Diagnosis, Yaws -- Treatment -- Simulation methods
Journal or Publication Title: Emerging Infectious Diseases
Publisher: US Department of Health and Human Services
ISSN: 1080-6059
Official Date: November 2020
Dates:
DateEvent
November 2020Published
8 October 2020Available
28 July 2020Accepted
Volume: 26
Number: 11
Page Range: pp. 2685-2693
DOI: 10.3201/eid2611.191491
Status: Peer Reviewed
Publication Status: Published
Publisher Statement: Holmes A, Tildesley MJ, Solomon AW, Mabey D, Sokana O, Marks M, et al. Modeling Treatment Strategies to Inform Yaws Eradication. Emerg Infect Dis. 2020;26(11):2685-2693. https://dx.doi.org/10.3201/eid2611.191491
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
102807/Z/13/ZWellcome Trusthttp://dx.doi.org/10.13039/100010269
098521Wellcome Trusthttp://dx.doi.org/10.13039/100010269
ARIES 203145Department for International Developmenthttp://dx.doi.org/10.13039/501100000278
AID-OAA-A-11-00048United States Agency for International Developmenthttp://dx.doi.org/10.13039/100000200
OAA-A-10-00051United States Agency for International Developmenthttp://dx.doi.org/10.13039/100000200
EP/L015374/1[EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
EP/L015374/1[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
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