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Serogroups of Dichelobacter nodosus, the cause of footrot in sheep, are randomly distributed across England
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Prosser, Naomi S., Monaghan, Emma M., Green, Laura E. and Purdy, Kevin J. (2020) Serogroups of Dichelobacter nodosus, the cause of footrot in sheep, are randomly distributed across England. Scientific Reports, 10 (1). 16823 . doi:10.1038/s41598-020-73750-5 ISSN 2045-2322.
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Official URL: https://doi.org/10.1038/s41598-020-73750-5
Abstract
We present the largest and most representative study of the serological diversity of Dichelobacter nodosus in England. D. nodosus causes footrot and is one of the top five globally important diseases of sheep. The commercial vaccine, containing nine serogroups, has low efficacy compared with bivalent vaccines. Our aim was to investigate the prevalence and distribution of serogroups of D. nodosus in England to elucidate whether a bivalent vaccine could protect the national flock. Farmers from 164 flocks submitted eight interdigital swabs from eight, preferably diseased, sheep. All serogroups, A–I, were detected by PCR in 687/1150 D. nodosus positive swabs, with a prevalence of 2.6–69.3% of positive swabs per serogroup. There was a median of two serogroups per flock (range 0–6). Serogroups were randomly distributed between, but clustered within, flocks, with 50 combinations of serogroups across flocks. H and B were the most prevalent serogroups, present in > 60% of flocks separately but in only 27% flocks together. Consequently, a bivalent vaccine targeting these two serogroups would protect 27% of flocks fully (if only H and B present) and partially, if more serogroups were present in the flock. We conclude that one bivalent vaccine would not protect the national flock against footrot and, with 50 combinations of serogroups in flocks, flock-specific vaccines are necessary.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Subjects: | S Agriculture > SF Animal culture | ||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
| SWORD Depositor: | Library Publications Router | ||||||
| Library of Congress Subject Headings (LCSH): | Footrot in sheep -- Research, Dichelobacter nodosus | ||||||
| Journal or Publication Title: | Scientific Reports | ||||||
| Publisher: | Nature Publishing Group UK | ||||||
| ISSN: | 2045-2322 | ||||||
| Official Date: | 8 October 2020 | ||||||
| Dates: |
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| Volume: | 10 | ||||||
| Number: | 1 | ||||||
| Article Number: | 16823 | ||||||
| DOI: | 10.1038/s41598-020-73750-5 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Date of first compliant deposit: | 15 October 2020 | ||||||
| Date of first compliant Open Access: | 15 October 2020 | ||||||
| RIOXX Funder/Project Grant: |
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