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Incidence of sudden cardiac death in the young : a systematic review
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Couper, Keith, Putt, Oliver, Field, Richard, Poole, Kurtis, Bradlow, William , Clarke, Aileen, Perkins, Gavin D., Royle, Pamela, Yeung, Joyce and Taylor-Phillips, Sian (2020) Incidence of sudden cardiac death in the young : a systematic review. BMJ Open, 10 (10). e040815. doi:10.1136/bmjopen-2020-040815 ISSN 2044-6055.
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Official URL: https://doi.org/10.1136/bmjopen-2020-040815
Abstract
Objective: To summarise studies describing incidence of sudden cardiac death in a general population of young individuals to inform screening policy. Design: Systematic review. Data sources: Database searches of MEDLINE, EMBASE and the Cochrane library (all inception to current) on 29 April 2019 (updated 16 November 2019), and forward/backward citation tracking of eligible studies. Study eligibility criteria: All studies that reported incidence of sudden cardiac death in young individuals (12–39 years) in a general population, with no restriction on language or date. Planned subgroups were incidence by age, sex, race and athletic status (including military personnel). Data extraction: Two reviewers independently assessed study eligibility, extracted study data and assessed risk of bias using the Joanna Briggs Institute critical appraisal checklist for prevalence studies. Analysis: Reported incidence of sudden cardiac death in the young per 100 000 person-years. Results: 38 studies that reported incidence across five continents. We identified substantial heterogeneity in population, sudden cardiac death definition, and case ascertainment methods, precluding meta-analysis. Median reported follow-up years was 6.97 million (IQR 2.34 million–23.70 million) and number of sudden cardiac death cases was 64 (IQR 40–251). In the general population, the median of reported incidence was 1.7 sudden cardiac death per 100 000 person-years (IQR 1.3–2.6, range 0.75–11.9). Most studies (n=14, 54%) reported an incidence between one and two cases per 100 000 person-years. Incidence was higher in males and older individuals. Conclusions: This systematic review identified variability in the reported incidence of sudden cardiac death in the young across studies. Most studies reported an incidence between one and two cases per 100 000 person-years. PROSPERO registration number: CRD42019120563.
Item Type: | Journal Article | ||||||||||||
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Subjects: | R Medicine > RC Internal medicine R Medicine > RJ Pediatrics |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||||||||
SWORD Depositor: | Library Publications Router | ||||||||||||
Library of Congress Subject Headings (LCSH): | Cardiovascular system -- Diseases, Cardiovascular system -- Diseases -- Mortality, Cardiovascular system -- Diseases -- Patients , Heart -- Diseases -- Patients, Sudden death in adolescence | ||||||||||||
Journal or Publication Title: | BMJ Open | ||||||||||||
Publisher: | BMJ Publishing Group | ||||||||||||
ISSN: | 2044-6055 | ||||||||||||
Official Date: | 7 October 2020 | ||||||||||||
Dates: |
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Volume: | 10 | ||||||||||||
Number: | 10 | ||||||||||||
Article Number: | e040815 | ||||||||||||
DOI: | 10.1136/bmjopen-2020-040815 | ||||||||||||
Status: | Peer Reviewed | ||||||||||||
Publication Status: | Published | ||||||||||||
Reuse Statement (publisher, data, author rights): | ** Embargo end date: 07-10-2020 ** From BMJ via Jisc Publications Router ** History: received 22-05-2020; rev-recd 28-08-2020; accepted 04-09-2020; ppub 10-2020; epub 07-10-2020. ** Licence for this article starting on 07-10-2020: https://creativecommons.org/licenses/by/4.0/ | ||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||
Date of first compliant deposit: | 14 October 2020 | ||||||||||||
Date of first compliant Open Access: | 16 October 2020 | ||||||||||||
RIOXX Funder/Project Grant: |
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