Couper, Keith, Putt, Oliver, Field, Richard, Poole, Kurtis, Bradlow, William , Clarke, Aileen, Perkins, Gavin D., Royle, Pamela, Yeung, Joyce and Taylor-Phillips, Sian (2020) Incidence of sudden cardiac death in the young : a systematic review. BMJ Open, 10 (10). e040815. doi:10.1136/bmjopen-2020-040815

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Abstract

Objective: To summarise studies describing incidence of sudden cardiac death in a general population of young individuals to inform screening policy. Design: Systematic review. Data sources: Database searches of MEDLINE, EMBASE and the Cochrane library (all inception to current) on 29 April 2019 (updated 16 November 2019), and forward/backward citation tracking of eligible studies. Study eligibility criteria: All studies that reported incidence of sudden cardiac death in young individuals (12–39 years) in a general population, with no restriction on language or date. Planned subgroups were incidence by age, sex, race and athletic status (including military personnel). Data extraction: Two reviewers independently assessed study eligibility, extracted study data and assessed risk of bias using the Joanna Briggs Institute critical appraisal checklist for prevalence studies. Analysis: Reported incidence of sudden cardiac death in the young per 100 000 person-years. Results: 38 studies that reported incidence across five continents. We identified substantial heterogeneity in population, sudden cardiac death definition, and case ascertainment methods, precluding meta-analysis. Median reported follow-up years was 6.97 million (IQR 2.34 million–23.70 million) and number of sudden cardiac death cases was 64 (IQR 40–251). In the general population, the median of reported incidence was 1.7 sudden cardiac death per 100 000 person-years (IQR 1.3–2.6, range 0.75–11.9). Most studies (n=14, 54%) reported an incidence between one and two cases per 100 000 person-years. Incidence was higher in males and older individuals. Conclusions: This systematic review identified variability in the reported incidence of sudden cardiac death in the young across studies. Most studies reported an incidence between one and two cases per 100 000 person-years. PROSPERO registration number: CRD42019120563.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine R Medicine > RJ Pediatrics
Divisions:	Faculty of Medicine > Warwick Medical School
SWORD Depositor:	Library Publications Router
Library of Congress Subject Headings (LCSH):	Cardiovascular system -- Diseases, Cardiovascular system -- Diseases -- Mortality, Cardiovascular system -- Diseases -- Patients , Heart -- Diseases -- Patients, Sudden death in adolescence
Journal or Publication Title:	BMJ Open
Publisher:	BMJ Publishing Group
ISSN:	2044-6055
Official Date:	7 October 2020
Dates:	Date Event 7 October 2020 Published 4 September 2020 Accepted
Volume:	10
Number:	10
Article Number:	e040815
DOI:	10.1136/bmjopen-2020-040815
Status:	Peer Reviewed
Publication Status:	Published
Publisher Statement:	** Embargo end date: 07-10-2020 ** From BMJ via Jisc Publications Router ** History: received 22-05-2020; rev-recd 28-08-2020; accepted 04-09-2020; ppub 10-2020; epub 07-10-2020. ** Licence for this article starting on 07-10-2020: https://creativecommons.org/licenses/by/4.0/
Access rights to Published version:	Open Access
RIOXX Funder/Project Grant:	Project/Grant ID RIOXX Funder Name Funder ID UNSPECIFIED Public Health England http://dx.doi.org/10.13039/501100002141 UNSPECIFIED [NIHR] National Institute for Health Research http://dx.doi.org/10.13039/501100000272 CDF-2016- 09-018 [NIHR] National Institute for Health Research http://dx.doi.org/10.13039/501100000272

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