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Investigating the dynamic nature of supramolecular cyclic peptide polymer nanotubes
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Rho, Julia Yu-jung (2019) Investigating the dynamic nature of supramolecular cyclic peptide polymer nanotubes. PhD thesis, University of Warwick.
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Official URL: http://webcat.warwick.ac.uk/record=b3473808~S15
Abstract
Supramolecular interactions can be found throughout nature and are essential to most biological functions. The fundamental concept of molecules interacting with one another, covalently or non-covalently, is used to explain what is happening on a chemical level. For a long time, the assumption was that the properties of a molecule were governed primarily by the properties of the single molecule. With our growing understanding of chemistry it became harder to ignore the effect environment played on a system; therefore giving rise to the new idea that molecular interactions could not be ignored. Key concepts, such as coordination chemistry, the lock-and-key model and host-guest binding all elude to this notion of molecular interactions. The prefix ‘supra’ means ‘beyond the limits’ of or ‘outside of’ and from this the term ‘supramolecular’ has been used to denote the interactions outside the limits of the molecule. The distinction between ‘intra’ and ‘inter’ molecular is made by differentiating how the atoms are bonded together, either covalently or non-covalently.
Supramolecular polymers consist of molecules that spontaneously self-assemble with one another via non-covalent interactions. These structures can form a range of different morphologies on the nanoscale, such as nanofibers,1 nanoribbons2 and nanotubes.3 Examples of these systems can also be found in nature, such as actin and tubulin.4 Making synthetic supramolecular polymers via a ‘bottom up’ approach is a very appealing proposition for chemists.5 Using well-established organic chemistry we can manipulate the functionality of these unimers to systemically promote assembly, introduce secondary interactions and provide attachment sites for post-modification. This gives us endless possibility to design and tailor these materials for a wide range of applications.
Item Type: | Thesis (PhD) | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Supramolecular chemistry, Nanotubes, Cyclic peptides | ||||
Official Date: | May 2019 | ||||
Dates: |
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Institution: | University of Warwick | ||||
Theses Department: | Department of Chemistry | ||||
Thesis Type: | PhD | ||||
Publication Status: | Unpublished | ||||
Supervisor(s)/Advisor: | Perrier, Sebastien | ||||
Format of File: | |||||
Extent: | xxii, 147 leaves : illustrations, charts | ||||
Language: | eng |
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