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Reduced apparent fiber density in the white matter of premature-born adults
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Menegaux, Aurore, Hedderich, Dennis M., Bäuml, Josef G., Manoliu, Andrei, Daamen, Marcel, Berg, Ronja C., Preibisch, Christine, Zimmer, Claus, Boecker, Henning, Bartmann, Peter, Wolke, Dieter, Sorg, Christian and Stämpfli, Philipp (2020) Reduced apparent fiber density in the white matter of premature-born adults. Scientific Reports, 10 (1). 17214. doi:10.1038/s41598-020-73717-6
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Official URL: https://doi.org/10.1038/s41598-020-73717-6
Abstract
Premature-born adults exhibit lasting white matter alterations as demonstrated by widespread reduction in fractional anisotropy (FA) based on diffusion-weighted imaging (DWI). FA reduction, however, is non-specific for microscopic underpinnings such as aberrant myelination or fiber density (FD). Using recent advances in DWI, we tested the hypothesis of reduced FD in premature-born adults and investigated its link with the degree of prematurity and cognition. 73 premature- and 89 mature-born adults aged 25–27 years underwent single-shell DWI, from which a FD measure was derived using convex optimization modeling for microstructure informed tractography (COMMIT). Premature-born adults exhibited lower FD in numerous tracts including the corpus callosum and corona radiata compared to mature-born adults. These FD alterations were associated with both the degree of prematurity, as assessed via gestational age and birth weight, as well as with reduced cognition as measured by full-scale IQ. Finally, lower FD overlapped with lower FA, suggesting lower FD underlie unspecific FA reductions. Results provide evidence that premature birth leads to lower FD in adulthood which links with lower full-scale IQ. Data suggest that lower FD partly underpins FA reductions of premature birth but that other processes such as hypomyelination might also take place.
| Item Type: | Journal Article | |||||||||||||||||||||
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| Subjects: | Q Science > QP Physiology R Medicine > RJ Pediatrics |
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| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science > Psychology Faculty of Medicine > Warwick Medical School |
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| SWORD Depositor: | Library Publications Router | |||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Premature infants, Premature infants -- Growth, White matter | |||||||||||||||||||||
| Journal or Publication Title: | Scientific Reports | |||||||||||||||||||||
| Publisher: | Nature Publishing Group UK | |||||||||||||||||||||
| ISSN: | 2045-2322 | |||||||||||||||||||||
| Official Date: | 14 October 2020 | |||||||||||||||||||||
| Dates: |
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| Date of first compliant deposit: | 26 November 2020 | |||||||||||||||||||||
| Volume: | 10 | |||||||||||||||||||||
| Number: | 1 | |||||||||||||||||||||
| Article Number: | 17214 | |||||||||||||||||||||
| DOI: | 10.1038/s41598-020-73717-6 | |||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||
| Publisher Statement: | ** From Springer Nature via Jisc Publications Router ** History: received 03-04-2020; accepted 21-09-2020; registration 22-09-2020; epub 14-10-2020; online 14-10-2020; collection 12-2020. ** Licence for this article: https://creativecommons.org/licenses/by/4.0/ | |||||||||||||||||||||
| Access rights to Published version: | Open Access | |||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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