The Library
Interfacial energy constraints are sufficient to align cells over large distances
Tools
Tools
Tools
Tlili, S., Shagirov, M., Zhang, S. and Saunders, Timothy E. (2019) Interfacial energy constraints are sufficient to align cells over large distances. Working Paper. Cold Spring Harbor Laboratory: BioRxiv.
An open access version can be found in:
Official URL: http://dx.doi.org/10.1101/653535
Abstract
During development and wound healing, cells need to form long-ranged ordered structures to ensure precise formation of organs and repair damage. This requires cells to locate specific partner cells to which to adhere. How such cell matching reliably happens is an open problem, particularly in the presence of biological variability. Here, we use an equilibrium energy model to simulate how cell matching can occur with subcellular precision. A single parameter – encapsulating the competition between selective cell adhesion and cell elasticity – can reproduce experimental observations of cell alignment in the Drosophila embryonic heart. This demonstrates that adhesive differences between cells (in the case of the heart, mediated by filopodia interactions) are sufficient to drive cell matching without requiring cell rearrangements. The model can explain observed matching defects in mutant conditions and when there is significant biological variability. We also demonstrate that a dynamic vertex model gives results consistent with the equilibrium energy model. Overall, this work shows that equilibrium energy considerations are consistent with observed cell matching in cardioblasts, and has potential application to other systems, such as neuron connections and wound repair.
| Item Type: | Working or Discussion Paper (Working Paper) | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Medicine > Warwick Medical School > Biomedical Sciences Faculty of Medicine > Warwick Medical School |
||||
| Publisher: | BioRxiv | ||||
| Place of Publication: | Cold Spring Harbor Laboratory | ||||
| Book Title: | Interfacial energy constraints are sufficient to align cells over large distances | ||||
| Official Date: | 30 May 2019 | ||||
| Dates: |
|
||||
| DOI: | 10.1101/653535 | ||||
| Institution: | University of Warwick | ||||
| Access rights to Published version: | Open Access | ||||
| Open Access Version: |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
