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The JNK signaling links the CNS architectural organization to motor coordination in the Drosophila embryo
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Karkali, Katerina, Panayotou, George, Saunders, Timothy E. and Martín-Blanco, Enrique (2018) The JNK signaling links the CNS architectural organization to motor coordination in the Drosophila embryo. Working Paper. Cold Spring Harbor Laboratory: BioRxiv.
An open access version can be found in:
Official URL: http://dx.doi.org/10.1101/092486
Abstract
n any organism, the construction of the Central Nervous System (CNS) is a complex process that must comply with precise architectural rules. How it is attained and how it affects neural functionality are key issues to solve. In the Drosophila Ventral Nerve Cord (VNC), we uncovered a set of novel robust architectural elements (3D nodes) arranged in a precise pattern responding to a delicate balance on Jun-N-terminal kinase (JNK) signaling activity in specific pioneer neurons. This cascade controls axons and dendrites integrity and, non-autonomously, Fasciclin 2 (Fas 2) expression. A deficit in Fas 2 impairs the VNC architecture and condensation. Remarkably, the coordination of the embryonic motor activity essential for embryo hatching also responds to JNK activity in the same cells. Altogether, our data point to the JNK pathway as an essential element underpinning VNC robustness and reveal critical links between the architecture of the VNC and its functional optimization.
| Item Type: | Working or Discussion Paper (Working Paper) | ||||
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| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Medicine > Warwick Medical School > Biomedical Sciences Faculty of Medicine > Warwick Medical School |
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| Publisher: | BioRxiv | ||||
| Place of Publication: | Cold Spring Harbor Laboratory | ||||
| Book Title: | The JNK signaling links the CNS architectural organization to motor coordination in the Drosophila embryo | ||||
| Official Date: | 12 May 2018 | ||||
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| DOI: | 10.1101/092486 | ||||
| Institution: | University of Warwick | ||||
| Access rights to Published version: | Open Access | ||||
| Open Access Version: |
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