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The potential utility of abbreviated breast MRI (FAST MRI) as a tool for breast cancer screening : a systematic review and meta-analysis
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FAST MRI Study Group (Including: Geach, R., Jones, L. I., Harding, S. A., Marshall, A. (Andrea), Taylor-Phillips, Sian, McKeown-Keegan, S. and Dunn, Janet A.). (2021) The potential utility of abbreviated breast MRI (FAST MRI) as a tool for breast cancer screening : a systematic review and meta-analysis. Clinical Radiology, 76 (2). 154.e11-154.e22. doi:10.1016/j.crad.2020.08.032
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WRAP-potential-utility-abbreviated-breast-MRI-breast-cancer-Dunn-2020.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (1530Kb) | Preview |
Official URL: https://doi.org/10.1016/j.crad.2020.08.032
Abstract
To synthesise evidence comparing abbreviated breast magnetic resonance imaging (abMRI) to full-protocol MRI (fpMRI) in breast cancer screening. A systematic search was undertaken in multiple databases. Cohort studies without enrichment, presenting accuracy data of abMRI in screening, for any level of risk (population, moderate, high risk) were included. Level of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE). Meta-analyses (bivariate random effects model) were performed for abMRI, with fpMRI and histology from fpMRI-positive cases as reference standard, and with follow-up to symptomatic detection added to the fpMRI. The review also covers evidence comparing abMRI with mammographic techniques. The title and abstract review retrieved 23 articles. Five studies (six articles) were included (2,763 women, 3,251 screening rounds). GRADE assessment of the evidence was very low because the reference standard was interpreted with knowledge of the index test and biopsy was not obtained for all abMRI positives. The overall sensitivity for abMRI, with fpMRI (and histology for fpMRI positives) as reference standard, was 94.8% (95% confidence interval [CI] 85.5-98.2) and specificity as 94.6% (95% CI: 91.5-96.6). Three studies (1,450 women, 1,613 screening rounds) presented follow-up data, enabling comparison between abMRI and fpMRI. Sensitivities and specificities for abMRI did not differ significantly from those for fpMRI (p=0.83 and p=0.37, respectively). A very low level of evidence suggests abMRI could be accurate for breast cancer screening. Research is required, with follow-up to interval cancer, to determine the effect its use could have on clinical outcome. [Abstract copyright: Copyright © 2020 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.]
| Item Type: | Journal Article | |||||||||
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| Subjects: | R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| SWORD Depositor: | Library Publications Router | |||||||||
| Library of Congress Subject Headings (LCSH): | Breast -- Cancer -- Diagnosis, Medical screening, Breast -- Magnetic resonance imaging | |||||||||
| Journal or Publication Title: | Clinical Radiology | |||||||||
| Publisher: | Elsevier ; Royal College of Radiologists | |||||||||
| ISSN: | 0009-9260 | |||||||||
| Official Date: | February 2021 | |||||||||
| Dates: |
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| Volume: | 76 | |||||||||
| Number: | 2 | |||||||||
| Page Range: | 154.e11-154.e22 | |||||||||
| DOI: | 10.1016/j.crad.2020.08.032 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||
| Copyright Holders: | © 2020 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved. | |||||||||
| RIOXX Funder/Project Grant: |
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