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Reward vs non-reward sensitivity of the medial vs lateral orbitofrontal cortex relates to the severity of depressive symptoms

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Xie, Chao, Jia, Tianye, Rolls, Edmund T., Robbins, Trevor W., Sahakian, Barbara J., Zhang, Jie, Liu, Zhaowen, Cheng, Wei, Luo, Qiang, Zac Lo, Chun-Yi et al.
(2020) Reward vs non-reward sensitivity of the medial vs lateral orbitofrontal cortex relates to the severity of depressive symptoms. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging . doi:10.1016/j.bpsc.2020.08.017 (In Press)

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Official URL: http://dx.doi.org/10.1016/j.bpsc.2020.08.017

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Abstract

Background:
The orbitofrontal cortex (OFC) is implicated in depression. The hypothesis investigated was whether the OFC sensitivity to reward and non-reward is related to the severity of depressive symptoms.

Methods:
Activations in the monetary incentive delay task were measured in the IMAGEN cohort at age 14 (n=1877) and 19 (n=1140) with a longitudinal design. Clinically-relevant subgroups were compared at age 19 (high-severity group n=116; low-severity group n=206), and 14.

Results:
The medial OFC exhibited graded activation increases to reward; and the lateral OFC had graded activation increases to non-reward. In this general population, the medial and lateral OFC activations were associated with concurrent depressive symptoms at both age 14 and 19. In a stratified high-severity depressive symptom vs control comparison, the lateral OFC showed greater sensitivity for the magnitudes of activations related to non-reward (No-Win) in the high-severity group at age 19 (p=0.027), and the medial OFC showed decreased sensitivity to the reward magnitudes in the high-severity group at both age 14 (p=0.002) and 19 (p=0.002). In a longitudinal design, there was greater sensitivity to non-reward of the lateral OFC at age 14 for those who exhibited high depressive symptom severity later at age 19 (p=0.003).

Conclusions:
Activations in the lateral orbitofrontal cortex relate to sensitivity to not winning, were associated with high depressive symptom scores, and at 14 predicted the depressive symptoms at 16 and 19. Activations in the medial OFC were related to sensitivity to winning, and reduced reward sensitivity was associated with concurrent high depressive symptom scores.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine
R Medicine > RJ Pediatrics
Divisions: Faculty of Science > Computer Science
Library of Congress Subject Headings (LCSH): Depressed persons, Prefrontal cortex, Depression in adolescence , Cognition disorders , Affective disorders
Journal or Publication Title: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Publisher: Elsevier
ISSN: 2451-9022
Official Date: 10 September 2020
Dates:
DateEvent
10 September 2020Available
30 August 2020Accepted
Date of first compliant deposit: 4 November 2020
DOI: 10.1016/j.bpsc.2020.08.017
Status: Peer Reviewed
Publication Status: In Press
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
2018YFC1312900Key Technologies Research and Development Programhttp://dx.doi.org/10.13039/501100012165
2019YFA070950Key Technologies Research and Development Programhttp://dx.doi.org/10.13039/501100012165
81801773[NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
81873909[NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
91630314[NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
111 Project (B18015)[MEPRC] Ministry of Education of the People's Republic of Chinahttp://dx.doi.org/10.13039/501100002338
2018SHZDZX01Science and Technology Commission of Shanghai Municipalityhttp://dx.doi.org/10.13039/501100003399
16JC1420402Shanghai Science and Technology Development Foundationhttp://dx.doi.org/10.13039/100012543
18PJ1400900Shanghai Science and Technology Development Foundationhttp://dx.doi.org/10.13039/100012543
LSHM-CT- 2007-037286Sixth Framework Programmehttp://dx.doi.org/10.13039/100011103
695313Horizon 2020 Framework Programmehttp://dx.doi.org/10.13039/100010661
ERANID PR-ST-0416-10004Seventh Framework Programmehttp://dx.doi.org/10.13039/100011102
MR/N027558/1[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
602450Seventh Framework Programmehttp://dx.doi.org/10.13039/100011102
603016Seventh Framework Programmehttp://dx.doi.org/10.13039/100011102
115300-2Innovative Medicines Initiativehttp://dx.doi.org/10.13039/501100010767
MR/N000390/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
FORMASVetenskapsrådethttp://dx.doi.org/10.13039/501100004359
UNSPECIFIED[NIHR] National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
UNSPECIFIEDSouth London and Maudsley NHS Foundation Trusthttp://dx.doi.org/10.13039/100009362
UNSPECIFIEDKing's College Hospital NHS Foundation Trusthttp://dx.doi.org/10.13039/100010872
01GS08152Bundesministerium für Bildung und Forschunghttp://dx.doi.org/10.13039/501100002347
01EV0711Bundesministerium für Bildung und Forschunghttp://dx.doi.org/10.13039/501100002347
eMED SysAlc01ZX1311ABundesministerium für Bildung und Forschunghttp://dx.doi.org/10.13039/501100002347
01EE1406ABundesministerium für Bildung und Forschunghttp://dx.doi.org/10.13039/501100002347
01EE1406BBundesministerium für Bildung und Forschunghttp://dx.doi.org/10.13039/501100002347
SM 80/7-2[DFG] Deutsche Forschungsgemeinschafthttp://dx.doi.org/10.13039/501100001659
SFB 940/2[DFG] Deutsche Forschungsgemeinschafthttp://dx.doi.org/10.13039/501100001659
MR/R00465X/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
Human Brain Project (HBP SGA 2European Commissionhttp://dx.doi.org/10.13039/501100000780
AF12-NEUR0008-01 - WM2NA[ANR] Agence Nationale de la Recherchehttp://dx.doi.org/10.13039/501100001665
ANR-12-SAMA-0004[ANR] Agence Nationale de la Recherchehttp://dx.doi.org/10.13039/501100001665
UNSPECIFIEDFondation de Francehttp://dx.doi.org/10.13039/501100004431
UNSPECIFIEDFondation pour la Recherche Médicalehttp://dx.doi.org/10.13039/501100002915
UNSPECIFIEDMission Interministérielle de Lutte Contre les Drogues et les Conduites Addictiveshttp://dx.doi.org/10.13039/501100011000
UNSPECIFIEDAssistance Publique - Hôpitaux de Parishttp://dx.doi.org/10.13039/501100002738
Interface grantInstitut national de la santé et de la recherche médicalehttp://dx.doi.org/10.13039/501100001677
IDEX 2012Université Paris-Sudhttp://dx.doi.org/10.13039/501100007486
16/ERCD/3797National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
16/ERCD/3797Science Foundation Irelandhttp://dx.doi.org/10.13039/501100001602
RO1 MH085772-01A1National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
U54 EB020403National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
Contributors:
ContributionNameContributor ID
Research GroupIMAGEN Consortium, UNSPECIFIED

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