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Hypertension is associated with reduced hippocampal connectivity and impaired memory
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Feng, Ruiqing, Rolls, Edmund T., Cheng, Wei and Feng, Jianfeng (2020) Hypertension is associated with reduced hippocampal connectivity and impaired memory. EBioMedicine, 61 . 103082. doi:10.1016/j.ebiom.2020.103082
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Official URL: https://doi.org/10.1016/j.ebiom.2020.103082
Abstract
Background:
The objective was a large-scale analysis of the relation between hypertension, memory problems, and brain function.
Methods:
The study design was to measure the association between a history of hypertension, and the functional connectivity between 94 brain regions, and prospective and numeric memory, in 19,507 participants from the UK Biobank, with cross-validation in 1,002 participants in the Human Connectome Project, and 13,441 individuals in the second release of the UK Biobank. A history of hypertension was measured by whether individuals were admitted to hospital for the treatment of hypertension, with the control group admissions for other reasons.
Findings:
A history of hypertension was associated with reduced functional connectivity of the hippocampus, and with reduced prospective memory score (FDR correction p<0.01). The reduced functional connectivity mediated the association between the hypertension history and the prospective memory score. A graded linear relation between both the hippocampal functional connectivity and memory impairment, was found across a wide range of blood pressure (r=-0.04). In 502,537 participants from the UK Biobank, a history of hypertension was associated with impaired prospective memory (p = 9.1 × 10−41, Cohen's d=-0.08) and numeric memory (p = 4.7 × 10−24, Cohen's d=-0.10). The association between hypertension, functional connectivity, and impaired memory was cross-validated with 1,002 participants from the Human Connectome Project; and for functional connectivity in 13,441 individuals in the second release of the UK Biobank imaging dataset.
Interpretation:
The reduced functional connectivity of the hippocampus, and the memory impairments, both related to hypertension across a wide range of blood pressure, are important for clinical practice.
| Item Type: | Journal Article | ||||||||||||||||||||||||||||||
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| Subjects: | R Medicine > RC Internal medicine | ||||||||||||||||||||||||||||||
| Divisions: | Faculty of Science > Computer Science | ||||||||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Hypertension -- Complications, Memory disorders, Brain -- Degeneration | ||||||||||||||||||||||||||||||
| Journal or Publication Title: | EBioMedicine | ||||||||||||||||||||||||||||||
| Publisher: | Elsevier BV | ||||||||||||||||||||||||||||||
| ISSN: | 2352-3964 | ||||||||||||||||||||||||||||||
| Official Date: | 22 October 2020 | ||||||||||||||||||||||||||||||
| Dates: |
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| Volume: | 61 | ||||||||||||||||||||||||||||||
| Article Number: | 103082 | ||||||||||||||||||||||||||||||
| DOI: | 10.1016/j.ebiom.2020.103082 | ||||||||||||||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||||||||||||||
| Access rights to Published version: | Open Access | ||||||||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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