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A new role for histone demethylases in the maintenance of plant genome integrity

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Antunez-Sanchez, Javier, Naish, Matthew, Ramirez-Prado, Juan Sebastian, Ohno, Sho, Huang, Ying, Dawson, Alexander, Opassathian, Korawit, Manza-Mianza, Deborah, Ariel, Federico, Raynaud, Cécile, Wibowo, Anjar, Daron, Josquin, Ueda, Minako, Latrasse, David , Slotkin, R. Keith, Weigel, Detlef, Benhamed, Moussa and Gutierrez-Marcos, José F. (2020) A new role for histone demethylases in the maintenance of plant genome integrity. eLife, 9 . e58533. doi:10.7554/elife.58533

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Official URL: https://doi.org/10.7554/elife.58533

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Abstract

Histone modifications deposited by the Polycomb repressive complex 2 (PRC2) play a critical role in the control of growth, development, and adaptation to environmental fluctuations of most multicellular eukaryotes. The catalytic activity of PRC2 is counteracted by Jumonji-type (JMJ) histone demethylases, which shapes the genomic distribution of H3K27me3. Here, we show that two JMJ histone demethylases in Arabidopsis, EARLY FLOWERING 6 (ELF6) and RELATIVE OF EARLY FLOWERING 6 (REF6), play distinct roles in H3K27me3 and H3K27me1 homeostasis. We show that failure to reset these chromatin marks during sexual reproduction results in the transgenerational inheritance of histone marks, which cause a loss of DNA methylation at heterochromatic loci and transposon activation. Thus, Jumonji-type histone demethylases play a dual role in plants by helping to maintain transcriptional states through development and safeguard genome integrity during sexual reproduction.

Item Type: Journal Article
Subjects: Q Science > QK Botany
Q Science > QP Physiology
Divisions: Faculty of Science > Life Sciences (2010- )
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Plant genomes , Histones , Eukaryotic cells
Journal or Publication Title: eLife
Publisher: eLife Sciences Publications, Ltd
ISSN: 2050-084X
Official Date: 27 October 2020
Dates:
DateEvent
27 October 2020Published
26 October 2020Accepted
Volume: 9
Article Number: e58533
DOI: 10.7554/elife.58533
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Copyright Holders: © 2020, Antunez-Sanchez et al.
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
ERA-CAPS ProgramSeventh Framework Programmehttp://dx.doi.org/10.13039/100011102
UNSPECIFIEDInternational Max Planck Research School for Advanced Methods in Process and Systems Engineeringhttp://dx.doi.org/10.13039/501100012318
EpiGEN[ANR] Agence Nationale de la Recherchehttp://dx.doi.org/10.13039/501100001665
EpiGEN[CNRS] Centre National de la Recherche Scientifiquehttp://dx.doi.org/10.13039/501100004794
JP19H05676[JSPS] Japan Society for the Promotion of Sciencehttp://dx.doi.org/10.13039/501100001691
BB/L003023/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/N005279/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/N00194X/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/P02601X/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
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