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A new role for histone demethylases in the maintenance of plant genome integrity
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Antunez-Sanchez, Javier, Naish, Matthew, Ramirez-Prado, Juan Sebastian, Ohno, Sho, Huang, Ying, Dawson, Alexander, Opassathian, Korawit, Manza-Mianza, Deborah, Ariel, Federico, Raynaud, Cécile, Wibowo, Anjar, Daron, Josquin, Ueda, Minako, Latrasse, David , Slotkin, R. Keith, Weigel, Detlef, Benhamed, Moussa and Gutierrez-Marcos, José F. (2020) A new role for histone demethylases in the maintenance of plant genome integrity. eLife, 9 . e58533. doi:10.7554/elife.58533
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Official URL: https://doi.org/10.7554/elife.58533
Abstract
Histone modifications deposited by the Polycomb repressive complex 2 (PRC2) play a critical role in the control of growth, development, and adaptation to environmental fluctuations of most multicellular eukaryotes. The catalytic activity of PRC2 is counteracted by Jumonji-type (JMJ) histone demethylases, which shapes the genomic distribution of H3K27me3. Here, we show that two JMJ histone demethylases in Arabidopsis, EARLY FLOWERING 6 (ELF6) and RELATIVE OF EARLY FLOWERING 6 (REF6), play distinct roles in H3K27me3 and H3K27me1 homeostasis. We show that failure to reset these chromatin marks during sexual reproduction results in the transgenerational inheritance of histone marks, which cause a loss of DNA methylation at heterochromatic loci and transposon activation. Thus, Jumonji-type histone demethylases play a dual role in plants by helping to maintain transcriptional states through development and safeguard genome integrity during sexual reproduction.
| Item Type: | Journal Article | ||||||||||||||||||||||||||||||
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| Subjects: | Q Science > QK Botany Q Science > QP Physiology |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||||||||||||||||||||||||||
| SWORD Depositor: | Library Publications Router | ||||||||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Plant genomes , Histones , Eukaryotic cells | ||||||||||||||||||||||||||||||
| Journal or Publication Title: | eLife | ||||||||||||||||||||||||||||||
| Publisher: | eLife Sciences Publications, Ltd | ||||||||||||||||||||||||||||||
| ISSN: | 2050-084X | ||||||||||||||||||||||||||||||
| Official Date: | 27 October 2020 | ||||||||||||||||||||||||||||||
| Dates: |
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| Volume: | 9 | ||||||||||||||||||||||||||||||
| Article Number: | e58533 | ||||||||||||||||||||||||||||||
| DOI: | 10.7554/elife.58533 | ||||||||||||||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||||||||||||||
| Access rights to Published version: | Open Access | ||||||||||||||||||||||||||||||
| Copyright Holders: | © 2020, Antunez-Sanchez et al. | ||||||||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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