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Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020

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Thompson, Craig P., Grayson, Nicholas E., Paton, Robert S., Bolton, Jai S., Lourenço, José, Penman, Bridget S., Lee, Lian N., Odon, Valerie, Mongkolsapaya, Juthathip, Chinnakannan, Senthil et al.
(2020) Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020. Eurosurveillance, 25 (42). 2000685. doi:10.2807/1560-7917.es.2020.25.42.2000685

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Abstract

Background
The progression and geographical distribution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the United Kingdom (UK) and elsewhere is unknown because typically only symptomatic individuals are diagnosed. We performed a serological study of blood donors in Scotland in the spring of 2020 to detect neutralising antibodies to SARS-CoV-2 as a marker of past infection and epidemic progression.

Aim
Our objective was to determine if sera from blood bank donors can be used to track the emergence and progression of the SARS-CoV-2 epidemic.

Methods
A pseudotyped SARS-CoV-2 virus microneutralisation assay was used to detect neutralising antibodies to SARS-CoV-2. The study comprised samples from 3,500 blood donors collected in Scotland between 17 March and 18 May 2020. Controls were collected from 100 donors in Scotland during 2019.

Results
All samples collected on 17 March 2020 (n = 500) were negative in the pseudotyped SARS-CoV-2 virus microneutralisation assay. Neutralising antibodies were detected in six of 500 donors from 23 to 26 March. The number of samples containing neutralising antibodies did not significantly rise after 5–6 April until the end of the study on 18 May. We found that infections were concentrated in certain postcodes, indicating that outbreaks of infection were extremely localised. In contrast, other areas remained comparatively untouched by the epidemic.

Conclusion
Although blood donors are not representative of the overall population, we demonstrated that serosurveys of blood banks can serve as a useful tool for tracking the emergence and progression of an epidemic such as the SARS-CoV-2 outbreak.

Item Type: Journal Article
Subjects: Q Science > QR Microbiology
R Medicine > RA Public aspects of medicine
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Science > Life Sciences (2010- )
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): COVID-19 (Disease) , Blood donors , Blood donors -- Scotland, Immunoglobulins, COVID-19 (Disease) -- Immunological aspects
Journal or Publication Title: Eurosurveillance
Publisher: European Centre for Disease Control and Prevention (ECDC)
ISSN: 1560-7917
Official Date: 22 October 2020
Dates:
DateEvent
22 October 2020Published
14 October 2020Accepted
Volume: 25
Number: 42
Article Number: 2000685
DOI: 10.2807/1560-7917.es.2020.25.42.2000685
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDGeorg and Emily Opel FoundationUNSPECIFIED
MC_PC_19059[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
UNSPECIFIED[NIHR] National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
2018-I2M-2-002Chinese Academy of Medical Scienceshttp://dx.doi.org/10.13039/501100005150
UNSPECIFIEDP. A. Messerschmidt og Hustrus Fondhttp://dx.doi.org/10.13039/501100008274
095541/A/11/ZWellcome Trusthttp://dx.doi.org/10.13039/100010269
WT109965/MAWellcome Trusthttp://dx.doi.org/10.13039/100010269
WTIA Grant WT104748MA)Wellcome Trusthttp://dx.doi.org/10.13039/100010269
MR/L006588/1[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
UNIFLUVACEuropean Research Councilhttp://dx.doi.org/10.13039/501100000781
BR00140[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
C30332/A23521Cancer Research UKhttp://dx.doi.org/10.13039/501100000289
212176Wellcome Trusthttp://dx.doi.org/10.13039/100010269
Research Capability Funding grant[NIHR] National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
NIHR200907[NIHR] National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
UNSPECIFIEDNIHR Oxford Biomedical Research Centrehttp://dx.doi.org/10.13039/501100013373

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