UNSPECIFIED (1999) Do we need 3 doses of hepatitis B vaccine? VACCINE, 17 (20-21). pp. 2667-2673. ISSN 0264-410X

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Abstract

The hepatitis B virus (HBV) vaccine may provide protection through the clonal expansion of specific memory cells without necessarily having to produce high serum antibody levels. We develop a mathematical model which distinguishes between the accumulation of sensitive memory B and T-helper cells prior to a booster and the high circulating antibody levels present in an individual after a booster. We suggest this immune memory accumulates primarily in an antigen-independent fashion. These phenomena suggest individuals may be immune to infection six months after the priming vaccine dose(s) regardless of whether they receive a booster or not. This hypothesis is supported by immunogenicity data and by two independent vaccine efficacy trials comparing 0, 1 month schedules with 0, 1 and 6 month schedules. (C) 1999 Elsevier Science Ltd. All rights reserved.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology > QR180 Immunology R Medicine
Journal or Publication Title:	VACCINE
Publisher:	ELSEVIER SCI LTD
ISSN:	0264-410X
Date:	4 June 1999
Volume:	17
Number:	20-21
Number of Pages:	7
Page Range:	pp. 2667-2673
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/14399

Data sourced from Thomson Reuters' Web of Knowledge

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