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Do we need 3 doses of hepatitis B vaccine?
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UNSPECIFIED (1999) Do we need 3 doses of hepatitis B vaccine? VACCINE, 17 (20-21). pp. 2667-2673. ISSN 0264-410X.
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Abstract
The hepatitis B virus (HBV) vaccine may provide protection through the clonal expansion of specific memory cells without necessarily having to produce high serum antibody levels. We develop a mathematical model which distinguishes between the accumulation of sensitive memory B and T-helper cells prior to a booster and the high circulating antibody levels present in an individual after a booster. We suggest this immune memory accumulates primarily in an antigen-independent fashion. These phenomena suggest individuals may be immune to infection six months after the priming vaccine dose(s) regardless of whether they receive a booster or not. This hypothesis is supported by immunogenicity data and by two independent vaccine efficacy trials comparing 0, 1 month schedules with 0, 1 and 6 month schedules. (C) 1999 Elsevier Science Ltd. All rights reserved.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QR Microbiology > QR180 Immunology R Medicine |
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| Journal or Publication Title: | VACCINE | ||||
| Publisher: | ELSEVIER SCI LTD | ||||
| ISSN: | 0264-410X | ||||
| Official Date: | 4 June 1999 | ||||
| Dates: |
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| Volume: | 17 | ||||
| Number: | 20-21 | ||||
| Number of Pages: | 7 | ||||
| Page Range: | pp. 2667-2673 | ||||
| Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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