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Do we need 3 doses of hepatitis B vaccine?
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UNSPECIFIED. (1999) Do we need 3 doses of hepatitis B vaccine? VACCINE, 17 (20-21). pp. 2667-2673. ISSN 0264-410X
Full text not available from this repository.Abstract
The hepatitis B virus (HBV) vaccine may provide protection through the clonal expansion of specific memory cells without necessarily having to produce high serum antibody levels. We develop a mathematical model which distinguishes between the accumulation of sensitive memory B and T-helper cells prior to a booster and the high circulating antibody levels present in an individual after a booster. We suggest this immune memory accumulates primarily in an antigen-independent fashion. These phenomena suggest individuals may be immune to infection six months after the priming vaccine dose(s) regardless of whether they receive a booster or not. This hypothesis is supported by immunogenicity data and by two independent vaccine efficacy trials comparing 0, 1 month schedules with 0, 1 and 6 month schedules. (C) 1999 Elsevier Science Ltd. All rights reserved.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QR Microbiology > QR180 Immunology R Medicine |
| Journal or Publication Title: | VACCINE |
| Publisher: | ELSEVIER SCI LTD |
| ISSN: | 0264-410X |
| Date: | 4 June 1999 |
| Volume: | 17 |
| Number: | 20-21 |
| Number of Pages: | 7 |
| Page Range: | pp. 2667-2673 |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/14399 |
Data sourced from Thomson Reuters' Web of Knowledge
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