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Do we need 3 doses of hepatitis B vaccine?

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UNSPECIFIED (1999) Do we need 3 doses of hepatitis B vaccine? VACCINE, 17 (20-21). pp. 2667-2673. ISSN 0264-410X.

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Abstract

The hepatitis B virus (HBV) vaccine may provide protection through the clonal expansion of specific memory cells without necessarily having to produce high serum antibody levels. We develop a mathematical model which distinguishes between the accumulation of sensitive memory B and T-helper cells prior to a booster and the high circulating antibody levels present in an individual after a booster. We suggest this immune memory accumulates primarily in an antigen-independent fashion. These phenomena suggest individuals may be immune to infection six months after the priming vaccine dose(s) regardless of whether they receive a booster or not. This hypothesis is supported by immunogenicity data and by two independent vaccine efficacy trials comparing 0, 1 month schedules with 0, 1 and 6 month schedules. (C) 1999 Elsevier Science Ltd. All rights reserved.

Item Type: Journal Article
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine
Journal or Publication Title: VACCINE
Publisher: ELSEVIER SCI LTD
ISSN: 0264-410X
Official Date: 4 June 1999
Dates:
DateEvent
4 June 1999UNSPECIFIED
Volume: 17
Number: 20-21
Number of Pages: 7
Page Range: pp. 2667-2673
Publication Status: Published

Data sourced from Thomson Reuters' Web of Knowledge

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