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Exploiting retrograde transport of Shiga-like toxin 1 for the delivery of exogenous antigens into the MHC class I presentation pathway
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UNSPECIFIED (1999) Exploiting retrograde transport of Shiga-like toxin 1 for the delivery of exogenous antigens into the MHC class I presentation pathway. FEBS LETTERS, 453 (1-2). pp. 95-99. ISSN 0014-5793
Full text not available from this repository.Abstract
Shiga-like toxin 1 (SLT) from Escherichia coli O157:H7 enters mammalian cells by endocytosis from the cell surface to the endoplasmic reticulum before translocating into the cytosol. Here, SLT mas engineered at its N- or C-terminus to carry a peptide derived from influenza virus Matrix protein for delivery to major histocompatibility complex (MHC) class I molecules, We show that SLT N-Ma was capable of sensitising cells for lysis by appropriate cytotoxic T-lymphocytes whilst no killing of SLT-resistant cells was observed. Our results demonstrate that peptide was liberated intracellularly and that retrograde transport of a disarmed cytotoxic protein can intersect the MHC class 1 presentation pathway. (C) 1999 Federation of European Biochemical Societies.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Journal or Publication Title: | FEBS LETTERS |
| Publisher: | ELSEVIER SCIENCE BV |
| ISSN: | 0014-5793 |
| Date: | 18 June 1999 |
| Volume: | 453 |
| Number: | 1-2 |
| Number of Pages: | 5 |
| Page Range: | pp. 95-99 |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/14415 |
Data sourced from Thomson Reuters' Web of Knowledge
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