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Screening to identify postoperative pain and cross-sectional associations between factors identified in this process with pain and function, three months after total knee replacement
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Wylde, Vikki, Sanderson, Emily, Peters, Tim J., Bertram, Wendy, Howells, Nicholas, Bruce, Julie, Eccleston, Christopher and Gooberman-Hill, Rachael (2020) Screening to identify postoperative pain and cross-sectional associations between factors identified in this process with pain and function, three months after total knee replacement. Arthritis Care & Research . doi:10.1002/acr.24516 (In Press)
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WRAP-Screening-identify-postoperative-pain-cross-sectional-factors-knee-replacement-Bruce-2020.pdf - Accepted Version - Requires a PDF viewer. Download (1357Kb) | Preview |
Official URL: https://doi.org/10.1002/acr.24516
Abstract
Objectives: Describe the screening and recruitment process of a randomised trial and evaluate associations with knee pain and function three months after total knee replacement (TKR).
Methods: To screen for a multi-centre trial, 5036 patients were sent an Oxford Knee Score (OKS) questionnaire 10 weeks post-TKR. Patients who reported pain in their replaced knee (≤14 on OKS pain component), completed a second OKS 12 weeks post-TKR. Those still experiencing pain 12 weeks post-TKR completed a detailed questionnaire 13 weeks post-TKR. These data were used to characterise pain in a cross-sectional analysis. Multivariable regression was performed, identifying factors associated with pain and function at 13 weeks post-TKR.
Results: We received OKS questionnaires from 3058/5063 (60%) TKR patients, 907/3058 (30%) reported pain in their replaced knee 10-weeks post-operatively. By 12-weeks, 179/553 (32%) patients reported improved pain (OKS>14). At 13-weeks, 192/363 (53%) who completed a detailed questionnaire reported neuropathic pain, 94/362 (26%) reported depression symptoms and 95/363 (26%) anxiety symptoms. More severe pain at 13-weeks post-operatively was associated with poorer general health, poorer physical health, more pain worry and lower satisfaction with surgery outcome. More severe functional limitation was associated with higher levels of depression, more pain worry, lower satisfaction with surgery outcome and higher pain acceptance.
Conclusions: Screening after TKR identified people with pain. We identified several potential targets (physical and mental health outcomes, acceptance of pain and quality of life) for tailored intervention to improve outcomes for patients. Trials of multidisciplinary interventions are now needed.
| Item Type: | Journal Article | |||||||||
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| Subjects: | R Medicine > RD Surgery | |||||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Total knee replacement, Knee -- Surgery, Chronic pain, Central pain, Neuralgia, Nervous system -- Pathophysiology, Postoperative care | |||||||||
| Journal or Publication Title: | Arthritis Care & Research | |||||||||
| Publisher: | Wiley-Blackwell Publishing Ltd. | |||||||||
| ISSN: | 2151-464X | |||||||||
| Official Date: | 18 November 2020 | |||||||||
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| DOI: | 10.1002/acr.24516 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | In Press | |||||||||
| Publisher Statement: | "This is the peer reviewed version of the following article: Wylde, V., Sanderson, E., Peters, T.J., Bertram, W., Howells, N., Bruce, J., Eccleston, C. and Gooberman‐Hill, R. (2020), Screening to identify postoperative pain and cross‐sectional associations between factors identified in this process with pain and function, three months after total knee replacement. Arthritis Care & Research. Accepted Author Manuscript., which has been published in final form at https://doi.org/10.1002/acr.24516. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions." | |||||||||
| Access rights to Published version: | Open Access | |||||||||
| Description: | Accepted version OA online early but no license |
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| RIOXX Funder/Project Grant: |
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