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Regulatory microRNAs in brown, brite and white adipose tissue
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Gharanei, Seley, Shabir, Kiran, Brown, James E. P., Weickert, Martin O., Barber, Thomas M., Kyrou, Ioannis and Randeva, Harpal S. (2020) Regulatory microRNAs in brown, brite and white adipose tissue. Cells, 9 (11). 2489. doi:10.3390/cells9112489 ISSN 2073-4409.
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WRAP-Regulatory-micro-RNAs-brown-brite-white-adipose-tissue-Barber-2020.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer. Download (1081Kb) |
Official URL: https://doi.org/10.3390/cells9112489
Abstract
MicroRNAs (miRNAs) constitute a class of short noncoding RNAs which regulate gene expression by targeting messenger RNA, inducing translational repression and messenger RNA degradation. This regulation of gene expression by miRNAs in adipose tissue (AT) can impact on the regulation of metabolism and energy homeostasis, particularly considering the different types of adipocytes which exist in mammals, i.e., white adipocytes (white AT; WAT), brown adipocytes (brown AT; BAT), and inducible brown adipocytes in WAT (beige or brite or brown-in-white adipocytes). Indeed, an increasing number of miRNAs has been identified to regulate key signaling pathways of adipogenesis in BAT, brite AT, and WAT by acting on transcription factors that promote or inhibit adipocyte differentiation. For example, MiR-328, MiR-378, MiR-30b/c, MiR-455, MiR-32, and MiR-193b-365 activate brown adipogenesis, whereas MiR-34a, MiR-133, MiR-155, and MiR-27b are brown adipogenesis inhibitors. Given that WAT mainly stores energy as lipids, whilst BAT mainly dissipates energy as heat, clarifying the effects of miRNAs in different types of AT has recently attracted significant research interest, aiming to also develop novel miRNA-based therapies against obesity, diabetes, and other obesity-related diseases. Therefore, this review presents an up-to-date comprehensive overview of the role of key regulatory miRNAs in BAT, brite AT, and WAT.
Item Type: | Journal Article | ||||||
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Subjects: | Q Science > QP Physiology | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Adipose tissues, Small interfering RNA, MicroRNA, Fat cells | ||||||
Journal or Publication Title: | Cells | ||||||
Publisher: | MDPI AG | ||||||
ISSN: | 2073-4409 | ||||||
Official Date: | 16 November 2020 | ||||||
Dates: |
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Volume: | 9 | ||||||
Number: | 11 | ||||||
Article Number: | 2489 | ||||||
DOI: | 10.3390/cells9112489 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 16 November 2020 | ||||||
Date of first compliant Open Access: | 18 December 2020 | ||||||
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