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Campylobacter jejuni 11168H exposed to penicillin forms persister cells and cells with altered redox protein activity

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Morcrette, Helen, Kovacs-Simon, Andrea, Tennant, Richard K., Love, John, Wagley, Sariqa, Yang, Zheng R., Studholme, David J., Soyer, Orkun S., Champion, Olivia L., Butler, Clive S. and Titball, Richard W. (2020) Campylobacter jejuni 11168H exposed to penicillin forms persister cells and cells with altered redox protein activity. Frontiers in Cellular and Infection Microbiology, 10 . 565975. doi:10.3389/fcimb.2020.565975

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Official URL: http://dx.doi.org/10.3389/fcimb.2020.565975

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Abstract

The formation of persister cells is one mechanism by which bacteria can survive exposure to environmental stresses. We show that Campylobacter jejuni 11168H forms persister cells at a frequency of 10−3 after exposure to 100 × MIC of penicillin G for 24 h. Staining the cell population with a redox sensitive fluorescent dye revealed that penicillin G treatment resulted in the appearance of a population of cells with increased fluorescence. We present evidence, to show this could be a consequence of increased redox protein activity in, or associated with, the electron transport chain. These data suggest that a population of penicillin G treated C. jejuni cells could undergo a remodeling of the electron transport chain in order to moderate membrane hyperpolarization and intracellular alkalization; thus reducing the antibiotic efficacy and potentially assisting in persister cell formation.

Item Type: Journal Article
Subjects: Q Science > QH Natural history
Q Science > QP Physiology
Q Science > QR Microbiology
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Campylobacter jejuni , Proteomics, Drug resistance in microorganisms, Antibiotics, Electron transport
Journal or Publication Title: Frontiers in Cellular and Infection Microbiology
Publisher: Frontiers Media
ISSN: 2235-2988
Official Date: 19 October 2020
Dates:
DateEvent
19 October 2020Published
11 September 2020Accepted
Date of first compliant deposit: 16 November 2020
Volume: 10
Article Number: 565975
DOI: 10.3389/fcimb.2020.565975
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
BB/N016513/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268

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