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Prediction of mortality in severe acute malnutrition in hospitalized children by faecal volatile organic compound analysis : proof of concept

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van den Brink, Deborah A., de Meij, Tim, Brals, Daniella, Bandsma, Robert H. J., Thitiri, Johnstone, Ngari, Moses, Mwalekwa, Laura, de Boer, Nanne K. H., Wicaksono, Alfian, Covington, James A., van Rheenen, Patrick F. and Voskuijl, Wieger P. (2020) Prediction of mortality in severe acute malnutrition in hospitalized children by faecal volatile organic compound analysis : proof of concept. Scientific Reports, 10 (1). 18785. doi:10.1038/s41598-020-75515-6 ISSN 2045-2322.

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Official URL: https://doi.org/10.1038/s41598-020-75515-6

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Abstract

Children with severe acute malnutrition (SAM) display immature, altered gut microbiota and have a high mortality risk. Faecal volatile organic compounds (VOCs) reflect the microbiota composition and may provide insight into metabolic dysfunction that occurs in SAM. Here we determine whether analysis of faecal VOCs could identify children with SAM with increased risk of mortality. VOC profiles from children who died within six days following admission were compared to those who were discharged alive using machine learning algorithms. VOC profiles of children who died could be separated from those who were discharged with fair accuracy (AUC) = 0.71; 95% CI 0.59-0.87; P = 0.004). We present the first study showing differences in faecal VOC profiles between children with SAM who survived and those who died. VOC analysis holds potential to help discover metabolic pathways within the intestinal microbiome with causal association with mortality and target treatments in children with SAM.Trial Registration: The F75 study is registered at clinicaltrials.gov/ct2/show/NCT02246296.

Item Type: Journal Article
Subjects: Q Science > QR Microbiology
R Medicine > RJ Pediatrics
Divisions: Faculty of Science, Engineering and Medicine > Engineering > Engineering
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Malnutrition in children -- Mortality, Gastrointestinal system -- Microbiology, Volatile organic compounds -- Health aspects
Journal or Publication Title: Scientific Reports
Publisher: Nature Publishing Group
ISSN: 2045-2322
Official Date: 5 November 2020
Dates:
DateEvent
5 November 2020Published
8 September 2020Accepted
Volume: 10
Number: 1
Article Number: 18785
DOI: 10.1038/s41598-020-75515-6
Status: Peer Reviewed
Publication Status: Published
Reuse Statement (publisher, data, author rights): ** From PubMed via Jisc Publications Router ** History: received 01-12-2019; accepted 08-09-2020.
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 7 December 2020
Date of first compliant Open Access: 7 December 2020
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
9403Thrasher Research Fundhttp://dx.doi.org/10.13039/100005627
OPP1131320Bill and Melinda Gates Foundationhttp://dx.doi.org/10.13039/100000865

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