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Prediction of mortality in severe acute malnutrition in hospitalized children by faecal volatile organic compound analysis : proof of concept
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van den Brink, Deborah A., de Meij, Tim, Brals, Daniella, Bandsma, Robert H. J., Thitiri, Johnstone, Ngari, Moses, Mwalekwa, Laura, de Boer, Nanne K. H., Wicaksono, Alfian, Covington, James A., van Rheenen, Patrick F. and Voskuijl, Wieger P. (2020) Prediction of mortality in severe acute malnutrition in hospitalized children by faecal volatile organic compound analysis : proof of concept. Scientific Reports, 10 (1). 18785. doi:10.1038/s41598-020-75515-6
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Official URL: https://doi.org/10.1038/s41598-020-75515-6
Abstract
Children with severe acute malnutrition (SAM) display immature, altered gut microbiota and have a high mortality risk. Faecal volatile organic compounds (VOCs) reflect the microbiota composition and may provide insight into metabolic dysfunction that occurs in SAM. Here we determine whether analysis of faecal VOCs could identify children with SAM with increased risk of mortality. VOC profiles from children who died within six days following admission were compared to those who were discharged alive using machine learning algorithms. VOC profiles of children who died could be separated from those who were discharged with fair accuracy (AUC) = 0.71; 95% CI 0.59-0.87; P = 0.004). We present the first study showing differences in faecal VOC profiles between children with SAM who survived and those who died. VOC analysis holds potential to help discover metabolic pathways within the intestinal microbiome with causal association with mortality and target treatments in children with SAM.Trial Registration: The F75 study is registered at clinicaltrials.gov/ct2/show/NCT02246296.
| Item Type: | Journal Article | |||||||||
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| Subjects: | Q Science > QR Microbiology R Medicine > RJ Pediatrics |
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| Divisions: | Faculty of Science > Engineering | |||||||||
| SWORD Depositor: | Library Publications Router | |||||||||
| Library of Congress Subject Headings (LCSH): | Malnutrition in children -- Mortality, Gastrointestinal system -- Microbiology, Volatile organic compounds -- Health aspects | |||||||||
| Journal or Publication Title: | Scientific Reports | |||||||||
| Publisher: | Nature Publishing Group | |||||||||
| ISSN: | 2045-2322 | |||||||||
| Official Date: | 5 November 2020 | |||||||||
| Dates: |
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| Volume: | 10 | |||||||||
| Number: | 1 | |||||||||
| Article Number: | 18785 | |||||||||
| DOI: | 10.1038/s41598-020-75515-6 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Publisher Statement: | ** From PubMed via Jisc Publications Router ** History: received 01-12-2019; accepted 08-09-2020. | |||||||||
| Access rights to Published version: | Open Access | |||||||||
| RIOXX Funder/Project Grant: |
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