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Regionalized tissue fluidization is required for epithelial gap closure during insect gastrulation
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Jain, Akanksha, Ulman, Vladimir, Mukherjee, Arghyadip, Prakash, Mangal, Cuenca, Marina B., Pimpale, Lokesh G., Münster, Stefan, Haase, Robert, Panfilio, Kristen A., Jug, Florian, Grill, Stephan W., Tomancak, Pavel and Pavlopoulos, Anastasios (2020) Regionalized tissue fluidization is required for epithelial gap closure during insect gastrulation. Nature Communications, 11 (1). 5604. doi:10.1038/s41467-020-19356-x ISSN 2041-1723.
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Official URL: http://dx.doi.org/10.1038/s41467-020-19356-x
Abstract
Many animal embryos pull and close an epithelial sheet around the ellipsoidal egg surface during a gastrulation process known as epiboly. The ovoidal geometry dictates that the epithelial sheet first expands and subsequently compacts. Moreover, the spreading epithelium is mechanically stressed and this stress needs to be released. Here we show that during extraembryonic tissue (serosa) epiboly in the insect Tribolium castaneum, the non-proliferative serosa becomes regionalized into a solid-like dorsal region with larger non-rearranging cells, and a more fluid-like ventral region surrounding the leading edge with smaller cells undergoing intercalations. Our results suggest that a heterogeneous actomyosin cable contributes to the fluidization of the leading edge by driving sequential eviction and intercalation of individual cells away from the serosa margin. Since this developmental solution utilized during epiboly resembles the mechanism of wound healing, we propose actomyosin cable-driven local tissue fluidization as a conserved morphogenetic module for closure of epithelial gaps.
Item Type: | Journal Article | |||||||||||||||||||||
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Subjects: | Q Science > QL Zoology | |||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Gastrulation, Embryos, Red flour beetle, Epithelium | |||||||||||||||||||||
Journal or Publication Title: | Nature Communications | |||||||||||||||||||||
Publisher: | Nature Publishing Group | |||||||||||||||||||||
ISSN: | 2041-1723 | |||||||||||||||||||||
Official Date: | 5 November 2020 | |||||||||||||||||||||
Dates: |
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Volume: | 11 | |||||||||||||||||||||
Number: | 1 | |||||||||||||||||||||
Article Number: | 5604 | |||||||||||||||||||||
DOI: | 10.1038/s41467-020-19356-x | |||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||||||||
Date of first compliant deposit: | 20 November 2020 | |||||||||||||||||||||
Date of first compliant Open Access: | 20 November 2020 | |||||||||||||||||||||
RIOXX Funder/Project Grant: |
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