Reversible activation of c-Myc in skin: Induction of a complex neoplastic phenotype by a single oncogenic lesion
UNSPECIFIED. (1999) Reversible activation of c-Myc in skin: Induction of a complex neoplastic phenotype by a single oncogenic lesion. MOLECULAR CELL, 3 (5). pp. 565-577. ISSN 1097-2765Full text not available from this repository.
The protooncogene c-myc regulates cell growth, differentiation, and apoptosis, and its aberrant expression is frequently observed in human cancer. However, the consequences of activating c-Myc in an adult tissue, in which these cellular processes are part of normal homeostasis, remain unknown. In order to achieve this, we have targeted expression of a switchable form of the c-Myc protein to the skin epidermis, a well characterized homeostatic tissue. We show that activation of c-MycER(TM) in adult suprabasal epidermis rapidly triggers proliferation and disrupts differentiation of postmitotic keratinocytes. Sustained activation of c-Myc is sufficient to induce papillomatosis together with angiogenesis-changes that resemble hyperplastic actinic keratosis, a commonly observed human precancerous epithelial lesion. All these premalignant changes spontaneously regress upon deactivation of c-MycER(TM).
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
|Journal or Publication Title:||MOLECULAR CELL|
|Number of Pages:||13|
|Page Range:||pp. 565-577|
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