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Reversible activation of c-Myc in skin: Induction of a complex neoplastic phenotype by a single oncogenic lesion
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UNSPECIFIED (1999) Reversible activation of c-Myc in skin: Induction of a complex neoplastic phenotype by a single oncogenic lesion. MOLECULAR CELL, 3 (5). pp. 565-577. ISSN 1097-2765
Full text not available from this repository.Abstract
The protooncogene c-myc regulates cell growth, differentiation, and apoptosis, and its aberrant expression is frequently observed in human cancer. However, the consequences of activating c-Myc in an adult tissue, in which these cellular processes are part of normal homeostasis, remain unknown. In order to achieve this, we have targeted expression of a switchable form of the c-Myc protein to the skin epidermis, a well characterized homeostatic tissue. We show that activation of c-MycER(TM) in adult suprabasal epidermis rapidly triggers proliferation and disrupts differentiation of postmitotic keratinocytes. Sustained activation of c-Myc is sufficient to induce papillomatosis together with angiogenesis-changes that resemble hyperplastic actinic keratosis, a commonly observed human precancerous epithelial lesion. All these premalignant changes spontaneously regress upon deactivation of c-MycER(TM).
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Journal or Publication Title: | MOLECULAR CELL |
| Publisher: | CELL PRESS |
| ISSN: | 1097-2765 |
| Date: | May 1999 |
| Volume: | 3 |
| Number: | 5 |
| Number of Pages: | 13 |
| Page Range: | pp. 565-577 |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/14481 |
Data sourced from Thomson Reuters' Web of Knowledge
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