The Library
Multiple introductions and predominance of 3 rotavirus group A genotype G3P[8] in Kilifi, coastal Kenya, 4 years after nationwide vaccine introduction
Tools
Tools
Tools
Mwanga, Mike J., Verani, Jennifer R., Omore, Richard, Tate, Jacqueline E., Parashar, Umesh D., Murunga, Nickson, Gicheru, Elijah, Breiman, Robert F., Nokes, D. James and Agoti, Charles N. (2020) Multiple introductions and predominance of 3 rotavirus group A genotype G3P[8] in Kilifi, coastal Kenya, 4 years after nationwide vaccine introduction. Pathogens, 9 (12). 981. doi:10.3390/pathogens9120981
|
PDF
WRAP-Multiple-introductions-predominance-rotavirus-A-genotype-coastal-Kenya-vaccine-Nokes-2020.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1194Kb) | Preview |
|
![[img]](http://wrap.warwick.ac.uk/style/images/fileicons/application_pdf.png) |
PDF
WRAP-Multiple-introductions-predominance-rotavirus-A-genotype-coastal-Kenya-vaccine-Nokes-2020.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer. Download (972Kb) |
Official URL: https://doi.org/10.3390/pathogens9120981
Abstract
Globally, rotavirus group A (RVA) remains a major cause of severe childhood diarrhea, despite the use of vaccines in more than 100 countries. RVA sequencing for local outbreaks facilitates investigation into strain composition, origins, spread, and vaccine failure. In 2018, we collected 248 stool samples from children aged less than 13 years admitted with diarrheal illness to Kilifi County Hospital, coastal Kenya. Antigen screening detected RVA in 55 samples (22.2%). Of these, VP7 (G) and VP4 (P) segments were successfully sequenced in 48 (87.3%) and phylogenetic analysis based on the VP7 sequences identified seven genetic clusters with six different GP combinations: G3P[8], G1P[8], G2P[4], G2P[8], G9P[8] and G12P[8]. The G3P[8] strains predominated the season (n = 37, 67.2%) and comprised three distinct G3 genetic clusters that fell within Lineage I and IX (the latter also known as equine-like G3 Lineage). Both the two G3 lineages have been recently detected in several countries. Our study is the first to document African children infected with G3 Lineage IX. These data highlight the global nature of RVA transmission and the importance of increasing global rotavirus vaccine coverage.
| Item Type: | Journal Article | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QR Microbiology > QR355 Virology R Medicine > RC Internal medicine |
||||||||||||||||||
| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Gastroenteritis -- Kenya -- Prevention, Rotaviruses -- Kenya, Phylogeny, Viral vaccines, Gastroenteritis in children | ||||||||||||||||||
| Journal or Publication Title: | Pathogens | ||||||||||||||||||
| Publisher: | MDPI | ||||||||||||||||||
| ISSN: | 2076-0817 | ||||||||||||||||||
| Official Date: | 24 November 2020 | ||||||||||||||||||
| Dates: |
|
||||||||||||||||||
| Volume: | 9 | ||||||||||||||||||
| Number: | 12 | ||||||||||||||||||
| Article Number: | 981 | ||||||||||||||||||
| DOI: | 10.3390/pathogens9120981 | ||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||
| Access rights to Published version: | Open Access | ||||||||||||||||||
| RIOXX Funder/Project Grant: |
|
||||||||||||||||||
| Related URLs: | |||||||||||||||||||
| Open Access Version: |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
