Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Evolution of respiratory syncytial virus genotype BA in Kilifi, Kenya, 15 years on

Tools
- Tools
+ Tools

Kamau, Everlyn , Otienoa, James R, Lewa, Clement S., Mwema , Anthony , Murunga, Nickson , Nokes, D. James and Agoti , Charles N. (2020) Evolution of respiratory syncytial virus genotype BA in Kilifi, Kenya, 15 years on. Scientific Reports, 10 . 21176 . doi:10.1038/s41598-020-78234-0 ISSN 2045-2322. [ šŸ—Ž Public]. [ (āœ“) hoa:511 ]

[img]
Preview
PDF
WRAP-Evolution-respiratory-syncytial-virus-genotype-BA-Kilifi-Kenya-Nokes-2020.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution 4.0.

Download (1895Kb) | Preview
[img] PDF
WRAP-Evolution-respiratory-syncytial-virus-genotype-BA-Kilifi-Kenya-Nokes-2020.pdf - Accepted Version
Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer.

Download (278Kb)
Official URL: https://doi.org/10.1038/s41598-020-78234-0

Request Changes to record.

Abstract

Respiratory syncytial virus (RSV) is recognised as a leading cause of severe acute respiratory disease and deaths among infants and vulnerable adults. Clinical RSV isolates can be divided into several known genotypes. RSV genotype BA, characterised by a 60-nucleotide duplication in the G glycoprotein gene, emerged in 1999 and quickly disseminated globally replacing other RSV group B genotypes. Continual molecular epidemiology is critical to understand the evolutionary processes maintaining the success of the BA viruses. We analysed 735 G gene sequences from samples collected from paediatric patients in Kilifi, Kenya, between 2003 and 2017. The virus population comprised of several genetically distinct variants (n = 56) co-circulating within and between epidemics. In addition, there was consistent seasonal fluctuations in relative genetic diversity. Amino acid changes increasingly accumulated over the surveillance period including two residues (N178S and Q180R) that mapped to monoclonal antibody 2D10 epitopes, as well as addition of putative N-glycosylation sequons. Further, switching and toggling of amino acids within and between epidemics was observed. On a global phylogeny, the BA viruses from different countries form geographically isolated clusters suggesting substantial localized variants. This study offers insights into longitudinal population dynamics of a globally endemic RSV genotype within a discrete location.

Item Type: Journal Article
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Respiratory syncytial virus -- Kenya, Respiratory organs -- Diseases -- Kenya
Journal or Publication Title: Scientific Reports
Publisher: Nature Publishing Group
ISSN: 2045-2322
Official Date: 3 December 2020
Dates:
DateEvent
3 December 2020Published
20 November 2020Accepted
Volume: 10
Article Number: 21176
DOI: 10.1038/s41598-020-78234-0
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 24 November 2020
Date of first compliant Open Access: 22 December 2020
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
102975Wellcome Trusthttp://dx.doi.org/10.13039/100010269
203077 Wellcome Trusthttp://dx.doi.org/10.13039/100010269
UNSPECIFIEDAfrican Academy of Scienceshttp://dx.doi.org/10.13039/501100011858
107769/Z/10/ZWellcome Trusthttp://dx.doi.org/10.13039/100010269
Related URLs:
  • Related dataset

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us