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The pathophysiology of bile acid diarrhoea : differences in the colonic microbiome, metabolome and bile acids
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Sagar, Nidhi M., Duboc, Henri, Kay, Gemma L., Alam, Mohammad T., Wicaksono, Alfian, Covington, James A., Quince, Christopher , Kokkorou, Margarita, Svolos, Vaios, Palmieri, Lola J., Gerasimidis, Konstantinos, Walters, Julian R. F. and Arasaradnam, Ramesh P. (2020) The pathophysiology of bile acid diarrhoea : differences in the colonic microbiome, metabolome and bile acids. Scientific Reports, 10 (1). 20436. doi:10.1038/s41598-020-77374-7
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Official URL: https://doi.org/10.1038/s41598-020-77374-7
Abstract
Bile acid diarrhoea (BAD) is a common disorder resulting from increased loss of bile acids (BAs), overlapping irritable bowel syndrome with diarrhoea (IBS-D). The gut microbiota metabolises primary BAs to secondary BAs, with differing impacts on metabolism and homeostasis. The aim of this study was to profile the microbiome, metabolic products and bile acids in BAD. Patients with BAD diagnosed by SeHCAT testing, were compared with other IBS-D patients, and healthy controls. Faecal 16S ribosomal RNA gene analysis was undertaken. Faecal short chain fatty acid (SCFA) and urinary volatile organic compounds (VOCs) were measured. BAs were quantified in serum and faeces. Faecal bacterial diversity was significantly reduced in patients with BAD. Several taxa were enriched compared to IBS-D. SCFA amounts differed in BAD, controls and IBS-D, with significantly more propionate in BAD. Separation of VOC profiles was evident, but the greatest discrimination was between IBS-D and controls. Unconjugated and primary BA in serum and faeces were significantly higher in BAD. The faecal percentage primary BA was inversely related to SeHCAT. BAD produces dysbiosis, with metabolite differences, including VOC, SCFA and primary BAs when compared to IBS-D. These findings provide new mechanistic insights into the pathophysiology of BAD.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | Q Science > QP Physiology Q Science > QR Microbiology R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science > Engineering Faculty of Medicine > Warwick Medical School |
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| SWORD Depositor: | Library Publications Router | ||||||||||||
| Library of Congress Subject Headings (LCSH): | Diarrhea, Bile acids, Gastrointestinal system -- Microbiology, Intestines -- Diseases | ||||||||||||
| Journal or Publication Title: | Scientific Reports | ||||||||||||
| Publisher: | Nature Publishing Group UK | ||||||||||||
| ISSN: | 2045-2322 | ||||||||||||
| Official Date: | 24 November 2020 | ||||||||||||
| Dates: |
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| Volume: | 10 | ||||||||||||
| Number: | 1 | ||||||||||||
| Article Number: | 20436 | ||||||||||||
| DOI: | 10.1038/s41598-020-77374-7 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Publisher Statement: | ** From Springer Nature via Jisc Publications Router ** History: received 25-08-2020; accepted 27-10-2020; registration 11-11-2020; online 24-11-2020; pub-electronic 24-11-2020; collection 12-2020. ** Licence for this article: http://creativecommons.org/licenses/by/4.0/ | ||||||||||||
| Access rights to Published version: | Open Access | ||||||||||||
| RIOXX Funder/Project Grant: |
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