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Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in Drosophila
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Jacomin, Anne-Claire, Gohel, Raksha, Hussain, Zunoon, Varga, Agnes, Maruzs, Tamas, Eddison, Mark, Sica, Margaux, Jain, Ashish, Moffat, Kevin G., Johansen, Terje, Jenny, Andreas, Juhasz, Gabor and Nezis, Ioannis P. (2021) Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in Drosophila. Life Science Alliance, 4 (2). e202000965. doi:10.26508/lsa.202000965
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Official URL: http://doi.org/10.26508/lsa.202000965
Abstract
Hunger drives food-seeking behaviour and controls adaptation of organisms to nutrient availability and energy stores. Lipids constitute an essential source of energy in the cell that can be mobilised during fasting by autophagy. Selective degradation of proteins by autophagy is made possible essentially by the presence of LIR and KFERQ-like motifs. Using in silico screening of Drosophila proteins that contain KFERQ-like motifs, we identified and characterized the adaptor protein Arouser, which functions to regulate fat storage and mobilisation and is essential during periods of food deprivation. We show that hypomorphic arouser mutants are not satiated, are more sensitive to food deprivation, and are more aggressive, suggesting an essential role for Arouser in the coordination of metabolism and food-related behaviour. Our analysis shows that Arouser functions in the fat body through nutrient-related signalling pathways and is degraded by endosomal microautophagy. Arouser degradation occurs during feeding conditions, whereas its stabilisation during non-feeding periods is essential for resistance to starvation and survival. In summary, our data describe a novel role for endosomal microautophagy in energy homeostasis, by the degradation of the signalling regulatory protein Arouser.
| Item Type: | Journal Article | |||||||||
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| Subjects: | Q Science > QH Natural history > QH426 Genetics Q Science > QP Physiology |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) | |||||||||
| Library of Congress Subject Headings (LCSH): | Proteins -- Metabolism, Lysosomes, Drosophila, Lipids -- Metabolism | |||||||||
| Journal or Publication Title: | Life Science Alliance | |||||||||
| Publisher: | Life Science Alliance | |||||||||
| ISSN: | 2575-1077 | |||||||||
| Official Date: | February 2021 | |||||||||
| Dates: |
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| Date of first compliant deposit: | 25 November 2020 | |||||||||
| Volume: | 4 | |||||||||
| Number: | 2 | |||||||||
| Article Number: | e202000965 | |||||||||
| DOI: | 10.26508/lsa.202000965 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Open Access | |||||||||
| Copyright Holders: | © 2020 Jacomin et al. | |||||||||
| RIOXX Funder/Project Grant: |
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