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Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in Drosophila

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Jacomin, Anne-Claire, Gohel, Raksha, Hussain, Zunoon, Varga, Agnes, Maruzs, Tamas, Eddison, Mark, Sica, Margaux, Jain, Ashish, Moffat, Kevin G., Johansen, Terje, Jenny, Andreas, Juhasz, Gabor and Nezis, Ioannis P. (2021) Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in Drosophila. Life Science Alliance, 4 (2). e202000965. doi:10.26508/lsa.202000965

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Official URL: http://doi.org/10.26508/lsa.202000965

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Abstract

Hunger drives food-seeking behaviour and controls adaptation of organisms to nutrient availability and energy stores. Lipids constitute an essential source of energy in the cell that can be mobilised during fasting by autophagy. Selective degradation of proteins by autophagy is made possible essentially by the presence of LIR and KFERQ-like motifs. Using in silico screening of Drosophila proteins that contain KFERQ-like motifs, we identified and characterized the adaptor protein Arouser, which functions to regulate fat storage and mobilisation and is essential during periods of food deprivation. We show that hypomorphic arouser mutants are not satiated, are more sensitive to food deprivation, and are more aggressive, suggesting an essential role for Arouser in the coordination of metabolism and food-related behaviour. Our analysis shows that Arouser functions in the fat body through nutrient-related signalling pathways and is degraded by endosomal microautophagy. Arouser degradation occurs during feeding conditions, whereas its stabilisation during non-feeding periods is essential for resistance to starvation and survival. In summary, our data describe a novel role for endosomal microautophagy in energy homeostasis, by the degradation of the signalling regulatory protein Arouser.

Item Type: Journal Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Q Science > QP Physiology
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Proteins -- Metabolism, Lysosomes, Drosophila, Lipids -- Metabolism
Journal or Publication Title: Life Science Alliance
Publisher: Life Science Alliance
ISSN: 2575-1077
Official Date: February 2021
Dates:
DateEvent
February 2021Published
14 December 2020Available
25 November 2020Accepted
Volume: 4
Number: 2
Article Number: e202000965
DOI: 10.26508/lsa.202000965
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Copyright Holders: © 2020 Jacomin et al.
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
BB/L006324/1 [BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/P007856/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
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